Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
Cristina Alonso,David Fernández-Ramos,Marta Varela-Rey,Ibon Martínez-Arranz,Nicolás Navasa,Sebastiaan M. Van Liempd,José Luis Lavín Trueba,Rebeca Mayo,Concetta P. Ilisso,Virginia Guitiérez de Juan,Marta Iruarrizaga-Lejarreta,Laura delaCruz-Villar,Itziar Mincholé,Aaron E. Robinson,Javier Crespo,Antonio Martín-Duce,Manuel Romero-Gómez,Holger Sann,Julian Platon,Jennifer E. Van Eyk,Patricia Aspichueta,Mazen Noureddin,Juan M. Falcón-Pérez,Juan Anguita,Ana M. Aransay,María L. Martínez-Chantar,Shelly C. Lu,José M. Mato +27 more
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TLDR
2 major subtypes of NAFLD are identified and markers that differentiate steatosis from NASH in each subtype are identified, used to monitor disease progression and identify therapeutic targets for patients.About:
This article is published in Gastroenterology.The article was published on 2017-05-01 and is currently open access. It has received 194 citations till now. The article focuses on the topics: Steatohepatitis & Nonalcoholic fatty liver disease.read more
Citations
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Mechanisms of NAFLD development and therapeutic strategies
TL;DR: Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression are discussed.
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MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease.
TL;DR: Experts reached consensus that NAFLD does not reflect current knowledge and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term and opens the door for efforts from the research community to update the nomenclature and sub-phenotype the disease in order to accelerate the translational path to new treatments.
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Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.
TL;DR: The current state of the noninvasive assessment of liver disease in NAFLD is summarized, and an expert synthesis of how these nonin invasive tools could be utilized in clinical practice is provided.
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Noninvasive biomarkers in NAFLD and NASH - current progress and future promise.
Vincent Wai-Sun Wong,Leon A. Adams,Victor de Lédinghen,Grace Lai-Hung Wong,Silvia Cristina Sookoian,Silvia Cristina Sookoian +5 more
TL;DR: Current and potential biomarkers for different features of NAFLD, namely, steatosis, necroinflammation and fibrosis are reviewed, and MRI-estimated proton density fat fraction is currently the most accurate test to quantify hepatic steatohepatitis and can be considered the gold standard.
Journal ArticleDOI
Nonalcoholic fatty liver disease: Evolving paradigms
Amedeo Lonardo,Fabio Nascimbeni,Mauro Maurantonio,Alessandra Marrazzo,Luca Rinaldi,Luigi Elio Adinolfi +5 more
TL;DR: NAFLD is highly prevalent in certain cohorts of individuals who are thus potentially amenable to selective screening strategies, intensive follow-up schedules for early identification of liver-related and extrahepatic complications and in whom earlier and more aggressive treatment schedules should be carried out whenever possible.
References
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David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
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Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search.
TL;DR: A statistical model is presented to estimate the accuracy of peptide assignments to tandem mass (MS/MS) spectra made by database search applications such as SEQUEST, demonstrating that the computed probabilities are accurate and have high power to discriminate between correctly and incorrectly assigned peptides.