Journal ArticleDOI
Metal ion interaction with penicillins— part VII: Mixed-ligand complex formation of cobalt(II), nickel(II), copper(II), and zinc(II) with amplicillin and nucleic bases
G. N. Mukherjee,Tapas Ghosh +1 more
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TLDR
Equilibrium study on the mixed-ligand complex formation of M2+ ions with alpha-d-(-)aminobenzyl penicillin popularly known as ampicillin and nucleic bases and stability constants of the ternary complexes.About:
This article is published in Journal of Inorganic Biochemistry.The article was published on 1995-09-01. It has received 52 citations till now. The article focuses on the topics: Thymine & Guanine.read more
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Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens
Andrew Wales,Robert Davies +1 more
TL;DR: The present review examines the evidence for the significance of co-selection for antibiotic resistance among bacteria exposed to biocides used as disinfectants, antiseptics and preservatives, and to heavy metals used as growth promoters and therapeutic agents for some livestock species.
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Heavy metals in liquid pig manure in light of bacterial antimicrobial resistance
Christina Hölzel,Christa Müller,Katrin S. Harms,Sabine Mikolajewski,Stefanie Schäfer,Karin Schwaiger,Johann Bauer +6 more
TL;DR: The presence of mercury was significantly associated with low antimicrobial resistance rates of Escherichia coli against β-lactams, aminoglycosides and other antibiotics, and effects of subinhibitory concentrations of mercury on bacterial resistance against penicillins, cephalosporins, am inoglycoside and doxycycline were demonstrated in a laboratory trial.
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The broader context of antibiotic resistance: Zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo
Carmen Bednorz,Kathrin Oelgeschläger,Bianca Kinnemann,Susanne Hartmann,Konrad Neumann,Robert Pieper,Astrid Bethe,Torsten Semmler,Karsten Tedin,Peter Schierack,Lothar H. Wieler,Sebastian Guenther +11 more
TL;DR: Characterization of subclones of E. coli clones in animals supplemented with zinc suggests an increase in antimicrobial resistance due to influences on plasmid uptake by zinc supplementation, questioning the reasonability of zinc feed additives as a result of the ban of antimicrobial growth promoters.
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Severe Zinc Depletion of Escherichia coli : Roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins
Alison I. Graham,Stuart Hunt,Sarah L. Stokes,Neil Bramall,Josephine Bunch,Alan G. Cox,Cameron W. McLeod,Robert K. Poole +7 more
TL;DR: Zn22+ elimination is shown to be a more precise method of depleting Zn2+ than by using the chelator N,N,N′, N′-tetrakis(2-pyridylmethyl)ethylenediamine.
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Chelation therapy for neurodegenerative diseases.
TL;DR: A survey of recent evidences supporting the use of a variety of metal ligands, and even functionalized nanoparticles, for the treatment of the most common ND, finding that the beneficial neuropharmacological actions of metal‐targeted agents most likely arise from local metal redistribution rather than from massive metal removal.
References
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Coordinating properties of the amide bond. Stability and structure of metal ion complexes of peptides and related ligands
Helmut Sigel,R. Bruce Martin +1 more
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Ternary Cu2+ Complexes: Stability, Structure, and Reactivity
TL;DR: In this article, the driving forces leading to the formation of ternary Cu2+ complexes are outlined; they are (i) statistical reasons, neutralization of charge in the mixed-ligand complexes, steric factors (bulky groups, ring size of chelates), and formation of π bonds.
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Computer calculation of equilibrium constants of species present in mixtures of metal ions and complexing agents.
TL;DR: The program, which employs the non-linear least-squares method, may be used to calculate equilibrium constants for hydrolysed metal ions, protonated ligands, and simple, Protonated, Hydrolysed, polynuclear, and mixed complexes.
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Metal Ions as Stabilizers or Destabilizers of the Deoxyribonucleic Acid Structure
TL;DR: Various divalent metal ions have been added in 10−4 M concentration to solutions of calf-thymus DNA in 5 × 10−3 M sodium nitrate, finding that the double-stranded helical configuration of DNA is stable in solutions containing as low as 10−2 M concentration of electrolyte.
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Complexing ability and coding properties of synthetic polynucleotides.
Wlodzimierz Szer,Severo Ochoa +1 more
TL;DR: Phenylalanine is a strong competitor of the incorporation of leucine promoted by poly U and related polynucleotides, and becomes more effective for polylysine synthesis as the temperature is raised from 20 to 45°C and the Mg 2+ concentration is slightly increased.