Journal ArticleDOI
Metal-on-metal bearings: THE EVIDENCE SO FAR
Fares S. Haddad,R. R. Thakrar,Alister Hart,John A. Skinner,A. V. F. Nargol,J. Nolan,Harinderjit Gill,David W. Murray,Ashley W Blom,C. P. Case +9 more
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TLDR
In this article, a review examines the literature and contemporary presentations on current clinical dilemmas in metal-on-metal hip replacement and concludes that the use of large metal on-metal bearings in hip replacements can result in catastrophic soft-tissue reactions resulting in implant failure and associated complications.Abstract:
Lately, concerns have arisen following the use of large metal-on-metal bearings in hip replacements owing to reports of catastrophic soft-tissue reactions resulting in implant failure and associated complications. This review examines the literature and contemporary presentations on current clinical dilemmas in metal-on-metal hip replacement.read more
Citations
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Journal ArticleDOI
Cobalt toxicity in humans—a review of the potential sources and systemic health effects
Laura Leyssens,Bart Vinck,Bart Vinck,Catherine Van Der Straeten,Catherine Van Der Straeten,Floris L. Wuyts,Leen Maes +6 more
TL;DR: Future research should focus on longitudinal studies in the clinical setting of MoM hip implant patients to further elucidate the dose-response discrepancies, and monitoring of the free fraction of Co2+ might be advisable for future risk assessment.
Journal ArticleDOI
Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the National Joint Registry of England and Wales
TL;DR: Metal-on-metal stemmed articulations give poor implant survival compared with other options and should not be implanted, and all patients with these bearings should be carefully monitored, particularly young women implanted with large diameter heads.
Journal ArticleDOI
Cobalt metabolism and toxicology--a brief update.
TL;DR: The biological functions of Cobalt are updated in the light of recent understanding of cobalt interference with the sensing in almost all animal cells of oxygen deficiency (hypoxia), and some of the toxic effects of cobALT (Co(2+)) have recently been proposed to be due to putative inhibition of Ca(2+) entry and Ca( 2+)-signaling and competition with Ca(3+)-binding proteins.
Journal ArticleDOI
Failure rates of metal-on-metal hip resurfacings: analysis of data from the National Joint Registry for England and Wales
TL;DR: Hip resurfacing only resulted in similar implant survivorship to other surgical options in men with large femoral heads, and inferior implant survival in other patients, particularly women, so it is recommended that resurfacing is not undertaken in women and that preoperative measurement is used to assess suitability in men.
Journal ArticleDOI
Corrosion at the neck-stem junction as a cause of metal ion release and pseudotumour formation
TL;DR: Dual modular cobalt-chrome hip prostheses should be used with caution due to concerns of corrosion at neck-stem tapers, which has been identified as an important source of metal ion release and pseudotumour formation requiring revision surgery.
References
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Journal ArticleDOI
Metal-on-metal bearings and hypersensitivity in patients with artificial hip joints. A clinical and histomorphological study.
Hans-Georg Willert,Gottfried Buchhorn,Afshin Fayyazi,Renata Flury,Markus Windler,Georg Köster,Christoph H. Lohmann +6 more
TL;DR: In this article, a study of the clinical data and periprosthetic tissues associated with endoprostheses with a metal-on-metal articulation that had been retrieved at revision was performed.
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Carcinogenic metal compounds : recent insight into molecular and cellular mechanisms
Detmar Beyersmann,Andrea Hartwig +1 more
TL;DR: In general, metal genotoxicity is caused by indirect mechanisms, but specific metal compounds exhibit unique mechanisms such as interruption of cell–cell adhesion by cadmium, direct DNA binding of trivalent chromium, and interaction of vanadate with phosphate binding sites of protein phosphatases.
Journal ArticleDOI
Pseudotumours associated with metal-on-metal hip resurfacings
Hemant Pandit,Sion Glyn-Jones,Peter McLardy-Smith,Roger Gundle,Duncan Whitwell,Christopher L. M. H. Gibbons,Simon Ostlere,Nicholas A. Athanasou,Harinderjit Gill,David W. Murray +9 more
TL;DR: The most common symptom was discomfort in the region of the hip and other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash as mentioned in this paper, and the common histological features were extensive necrosis and lymphocytic infiltration.
Journal ArticleDOI
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium.
TL;DR: Overall, metal carcinogenesis appears to require the formation of specific metal complexes, chromosomal damage, and activation of signal transduction pathways promoting survival and expansion of genetically/epigenetically altered cells.
Journal ArticleDOI
Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A CONSEQUENCE OF EXCESS WEAR
TL;DR: Surgeons must consider implant design, expected component size and acetabular component positioning in order to reduce early failures when performing large-bearing metal-on-metal hip resurfacing and replacement.