Journal ArticleDOI
Metal–Organic-Framework-Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy
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TLDR
Overall, this study demonstrates the advantages of metal–organic‐framework‐assisted bacteria metabolic labeling strategy for precise bacterial detection and therapy guided by fluorescence imaging.Abstract:
Bacterial infection is one of the most serious physiological conditions threatening human health. There is an increasing demand for more effective bacterial diagnosis and treatment through noninvasive theranostic approaches. Herein, a new strategy is reported to achieve in vivo metabolic labeling of bacteria through the use of MIL-100 (Fe) nanoparticles (NPs) as the nanocarrier for precise delivery of 3-azido-d-alanine (d-AzAla). After intravenous injection, MIL-100 (Fe) NPs can accumulate preferentially and degrade rapidly within the high H2 O2 inflammatory environment, releasing d-AzAla in the process. d-AzAla is selectively integrated into the cell walls of bacteria, which is confirmed by fluorescence signals from clickable DBCO-Cy5. Ultrasmall photosensitizer NPs with aggregation-induced emission characteristics are subsequently designed to react with the modified bacteria through in vivo click chemistry. Through photodynamic therapy, the amount of bacteria on the infected tissue can be significantly reduced. Overall, this study demonstrates the advantages of metal-organic-framework-assisted bacteria metabolic labeling strategy for precise bacterial detection and therapy guided by fluorescence imaging.read more
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Photosensitizers with Aggregation-Induced Emission: Materials and Biomedical Applications
Fang Hu,Shidang Xu,Bin Liu +2 more
TL;DR: In this paper, the design principles of aggregation-induced emission (AIE) PSs and their biomedical applications are discussed in detail, starting with a summary of traditional PSs, followed by a comparison between traditional and AIE PSs to highlight various design strategies and unique features of the latter.
Journal ArticleDOI
Photonic functional metal-organic frameworks.
TL;DR: The recent and important progress in the design and construction of photonic MOFs, as well as their various applications in luminescence sensing, white-light emission, photocatalysis, nonlinear optics, lasing devices, data storage, and biomedicine are summarized.
Journal ArticleDOI
Recent Advances of Optical Imaging in the Second Near-Infrared Window
Kenry,Yukun Duan,Bin Liu +2 more
TL;DR: The importance of biological imaging in the NIR‐II spectral region is highlighted, the emergence and latest development of various Nir‐II fluorescence and PA imaging probes and their applications are discussed, and Perspectives on the promises and challenges facing this nascent yet exciting field are given.
Journal ArticleDOI
Metal-Organic Frameworks for Biomedical Applications.
TL;DR: This work outlines the synthesis and functionalization and the recent advances of MOFs in biomedical fields, including cargo (drugs, nucleic acids, proteins, and dyes) delivery for cancer therapy, bioimaging, antimicrobial, biosensing, and biocatalysis.
Journal ArticleDOI
Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives.
TL;DR: Antibiotic‐free antibacterial strategies enabled by advanced nanomaterials are presented and practical antibacterial applications employing these antibiotic‐free strategies are introduced.
References
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Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
Patricia Horcajada,Tamim Chalati,Christian Serre,Brigitte Gillet,Catherine Sebrié,Tarek Baati,Jarrod F. Eubank,Daniela Heurtaux,Pascal Clayette,Christine Kreuz,Jong-San Chang,Young Kyu Hwang,Véronique Marsaud,Phuong-Nhi Bories,Luc Cynober,Sophie Gil,Gérard Férey,Patrick Couvreur,Ruxandra Gref +18 more
TL;DR: It is shown that specific non-toxic porous iron(III)-based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs against cancer and AIDS.
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Ming-Xue Wu,Ying-Wei Yang +1 more
TL;DR: A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.
Journal ArticleDOI
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Novel antibody–antibiotic conjugate eliminates intracellular S. aureus
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The Future of Antibiotics and Resistance
TL;DR: Antibiotic resistance and the collapse of the antibiotic research-and-development pipeline continue to worsen despite ongoing efforts, and new ideas that complement traditional approaches are needed.
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