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Metal Oxide Nanoparticles: Potential Uses in Biomedical Applications

About: This article is published in Current Proteomics.The article was published on 2014-06-30 and is currently open access. It has received 25 citations till now.
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TL;DR: The recent achievements in the large-scale synthesis of uniform-sized metal oxide nanoparticles and their biomedical applications are summarized, with a focus on nanoparticles of transition metal oxides and lanthanide oxides, and clarifying the underlying mechanism for the synthesis of Uniform-sized nanoparticles.
Abstract: Thanks to recent advances in the synthesis of high-quality inorganic nanoparticles, more and more types of nanoparticles are becoming available for medical applications. Especially, metal oxide nanoparticles have drawn much attention due to their unique physicochemical properties and relatively inexpensive production costs. To further promote the development and clinical translation of these nanoparticle-based agents, however, it is highly desirable to reduce unwanted interbatch variations of the nanoparticles because characterizing and refining each batch are costly, take a lot of effort, and, thus, are not productive. Large-scale synthesis is a straightforward and economic pathway to minimize this issue. Here, the recent achievements in the large-scale synthesis of uniform-sized metal oxide nanoparticles and their biomedical applications are summarized, with a focus on nanoparticles of transition metal oxides and lanthanide oxides, and clarifying the underlying mechanism for the synthesis of uniform-sized nanoparticles. Surface modification steps to endow hydrophobic nanoparticles with water dispersibility and biocompatibility are also briefly described. Finally, various medical applications of metal oxide nanoparticles, such as bioimaging, drug delivery, and therapy, are presented.

88 citations

Journal ArticleDOI
TL;DR: In this article, the microwave combustion synthesis method of Ca (on Zn site) and Gd (on Fe site) substituted ferrites was used to reduce particle sizes and to vary the cation distribution on the spinel sites.

54 citations

Journal ArticleDOI
TL;DR: In this article, the authors summarized the recent advances in the fabrication, modification, and industrial application of ZnO-photocatalyst based on the analysis of the latest studies, including the following aspects: overview on the properties, structures, and features of the znO, employment of dopants, heterojunction, and immobilization techniques for improved photodegradation performance, applicability of suspended and immobilized photocatalytic systems, application of ǫ-hybrid for the removal of various types of hazardous pollutants from different wastewater sources in industries, and

50 citations

Journal ArticleDOI
TL;DR: In this paper , the authors summarized the recent advances in the fabrication, modification, and industrial application of ZnO photocatalyst based on the analysis of the latest studies, including the following aspects: overview on the properties, structures, and features of zinc oxide, employment of dopants, heterojunction, and immobilization techniques for improved photodegradation performance, applicability of suspended and immobilized photocatalytic systems, application of znO hybrids for the removal of various types of hazardous pollutants from different wastewater sources in industries, and potential of bio-inspired ZnOs hybrid nanomaterials.

50 citations

Journal ArticleDOI
TL;DR: Current in vitro and in vivo studies regarding the use of nanoparticles as potential delivery devices for PSs to enhance their cellular uptake and cytotoxic properties, and thus-the therapeutic outcome of PDT are summarized.
Abstract: Photodynamic therapy (PDT) is a minimally invasive technique which has proven to be successful in the treatment of several types of tumors. This relatively simple method exploits three inseparable elements: phototoxic compound (photosensitizer [PS]), light source, and oxygen. Upon irradiation by light with specified wavelength, PS generates reactive oxygen species, which starts the cascade of reactions leading to cell death. The positive therapeutic outcome of PDT may be limited due to several aspects, including low water solubility of PSs, hampering their effective administration and blood circulation, as well as low tumor specificity, inefficient cellular uptake and activation energies requiring prolonged illumination times. One of the promising approaches to overcome these obstacles involves the use of carrier systems modulating pharmacokinetics and pharmacodynamics of the PSs. In the present review, we summarized current in vitro and in vivo studies regarding the use of nanoparticles as potential delivery devices for PSs to enhance their cellular uptake and cytotoxic properties, and thus-the therapeutic outcome of PDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

48 citations