Metallic nanoparticles for biomedical applications
01 Jan 2021-Vol. 16, pp 29-81
TL;DR: In this paper, the authors describe the top-down and bottom-up approach and current trends in the synthesis of metallic nanoparticles for biomedical purposes, and explain how the parameters can be tuned to get metallic particles with the desired shape, size, morphology, composition and crystallinity.
Abstract: Metallic nanoparticles have found various biomedical applications due to their intrinsic physicochemical properties. As the size decreases, the high surface area of particles gives rise to distinctive features, which are entirely different from that of a macro-sized structure. Several methods are involved in synthesizing metallic nanoparticles, and in general, it can be categorized into either bottom-up or top-down approaches. The top-down method consists of cutting down the bulk materials into nano-sized particles through physical, chemical, or mechanical treatments, whereas, in a bottom-up approach, nanoparticles are formed by joining individual atoms or molecules. The top-down approach produces metallic nanoparticles in naked form, which can further agglomerate and hence not suitable for biomedical applications. The bottom-up approach involves solid-state, liquid state, gas phase, biological, microfluidic-technology based, and other methods. Chemical reduction in the bottom-up approach is the most common method of metallic nanoparticle synthesis, which is flexible, simpler, inexpensive, and produces particles in homogenous form. Recently biological method of nanoparticle synthesis has become popular due to its toxic-free nature, inexpensiveness, sustainability, and eco-friendly. In this chapter, we describe the top-down and bottom-up approach and current trends in the synthesis of metallic nanoparticles for biomedical purposes. Further, it explains how the parameters can be tuned to get metallic nanoparticles with the desired shape, size, morphology, composition and crystallinity.
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01 Jan 2012
TL;DR: In it for the long haul: Clusters of Pt nanowires (3D Pt nanoassemblies, Pt NA) serve as an electrocatalyst for low-temperature fuel cells that exhibit remarkably high stability following thousands of voltage cycles and good catalytic activity, when compared with a commercial Pt’salyst and 20 % wt Pt”catalyst supported on carbon black.
Abstract: In it for the long haul: Clusters of Pt nanowires (3D Pt nanoassemblies, Pt NA) serve as an electrocatalyst for low-temperature fuel cells. These Pt nanoassemblies exhibit remarkably high stability following thousands of voltage cycles and good catalytic activity, when compared with a commercial Pt catalyst and 20 % wt Pt catalyst supported on carbon black (20 % Pt/CB).
207 citations
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TL;DR: This literature review shows that drug carriers based on magnetic nanoparticles can be efficiently used for the controlled release of drug at targeted locations mediated by various stimuli.
Abstract: ABSTRACT Introduction In the field of drug delivery, controlling the release of therapeutic substances at localized targets has become a primary focus of medical research, especially in the field of cancer treatment. Magnetic nanoparticles are one of the most promising drug carriers thanks to their biocompatibility and (super)paramagnetic properties. These properties allow for the combination between imaging modalities and specific release of drugs at target sites using either local stimulus (i.e. pH, conjugation of biomarkers, …) or external stimulus (i.e. external magnetic field). Areas covered This review provides an update on recent advances with the development of targeted drug delivery systems based on magnetic nanoparticles (MNPs). This overview focuses on active targeting strategies and systems combining both imaging and therapeutic modalities (i.e. theranostics). If most of the examples concern the particular case of cancer therapy, the possibility of using MNPs for other medical applications is also discussed. Expert opinion The development of clinically relevant drug delivery systems based on magnetic nanoparticles is driven by advantages stemming from their remarkable properties (i.e. easy preparation, facile chemical functionalization, biocompatibility, low toxicity, and superior magnetic responsiveness). This literature review shows that drug carriers based on magnetic nanoparticles can be efficiently used for the controlled release of drug at targeted locations mediated by various stimuli. Advances in the field should lead to the implementation of such systems into clinical trials, especially systems enabling drug tracking in the body.
15 citations
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TL;DR: In this paper , a review of recent progress in organic and inorganic nanomaterials based bioNEMS/MEMS for biomedical applications, comprehensively discussing nanommaterials criteria and their prospects as ideal tools for biomedical devices.
Abstract: bioNEMS/MEMS has emerged as an innovative technology for the miniaturisation of biomedical devices with high precision and rapid processing since its first R&D breakthrough in the 1980s. To date, several organic including food waste derived nanomaterials and inorganic nanomaterials (e.g., carbon nanotubes, graphene, silica, gold, and magnetic nanoparticles) have steered the development of high-throughput and sensitive bioNEMS/MEMS-based biosensors, actuator systems, drug delivery systems and implantable/wearable sensors with desirable biomedical properties. Turning food waste into valuable nanomaterials is potential groundbreaking research in this growing field of bioMEMS/NEMS. This review aspires to communicate recent progress in organic and inorganic nanomaterials based bioNEMS/MEMS for biomedical applications, comprehensively discussing nanomaterials criteria and their prospects as ideal tools for biomedical devices. We discuss clinical applications for diagnostic, monitoring, and therapeutic applications as well as the technological potential for cell manipulation (i.e., sorting, separation, and patterning technology). In addition, current in vitro and in vivo assessments of promising nanomaterials-based biomedical devices will be discussed in this review. Finally, this review also looked at the most recent state-of-the-art knowledge on Internet of Things (IoT) applications such as nanosensors, nanoantennas, nanoprocessors, and nanobattery.
7 citations
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TL;DR: In this paper , the characteristics and applications of the nanoparticles synthesized using the different taxa of fungi are reviewed, and the key focus is given to the applications of these nanoparticles in medicine and cosmetology.
Abstract: Abstract In today’s time, nanotechnology is being utilized to develop efficient products in the cosmetic and pharmaceutical industries. The application of nanotechnology in transforming bioactive material into nanoscale products substantially improves their biocompatibility and enhances their effectiveness, even when used in lower quantities. There is a significant global market potential for these nanoparticles because of which research teams around the world are interested in the advancements in nanotechnology. These recent advances have shown that fungi can synthesize metallic nanoparticles via extra- and intracellular mechanisms. Moreover, the chemical and physical properties of novel metallic nanoparticles synthesised by fungi are improved by regulating the surface chemistry, size, and surface morphology of the nanoparticles. Compared to chemical synthesis, the green synthesis of nanoparticles offers a safe and sustainable approach for developing nanoparticles. Biosynthesised nanoparticles can potentially enhance the bioactivities of different cellular fractions, such as plant extracts, fungal extracts, and metabolites. The nanoparticles synthesised by fungi offer a wide range of applications. Recently, the biosynthesis of nanoparticles using fungi has become popular, and various ways are being explored to maximize nanoparticles synthesis. This manuscript reviews the characteristics and applications of the nanoparticles synthesised using the different taxa of fungi. The key focus is given to the applications of these nanoparticles in medicine and cosmetology.
7 citations
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TL;DR: In this article, a nanosecond pulse laser-assisted photoporation using titanium-oxide nanotubes (TNT) for highly efficient intracellular delivery has been established.
Abstract: In the present study, a newly developed nanosecond pulse laser-assisted photoporation using titanium-oxide nanotubes (TNT) for highly efficient intracellular delivery has been established. The proof of concept for the possibilities of intracellular delivery after irradiation of nanosecond pulse laser on TNT has been validated. TNT on titanium sheets using the electrochemical anodization technique at different voltage and time has been developed. The extensive X-ray photoelectron spectroscopy (XPS) study confirms the presence of different titanium oxide species such as TiO2, TixOy (TiO/Ti2O3/Ti3O5) having different concentrations in TNT formed by different anodization voltage and time along with a minor quantity of Ti metal (Ti0). Formation of sub-oxides results in oxygen defects in TNT. It has also been evidenced from XPS that the anodization voltage and time can change the concentration of oxygen defects on the nanotubes. Due to the formation of oxygen defects, nanotubes have the quasi-metallic and metallic properties. These properties of the nanotubes may facilitate the intracellular delivery by various mechanisms after irradiation of nanosecond pulse laser. Using this technique, we successfully have delivered Propidium iodide (PI) and dextran into HeLa cells (HeLa- human cervical cancer cells) with high transfection efficiency and cell viability on nanotubes formed at 15 V/2 h.
5 citations
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TL;DR: The rates of reduction of the metal ions by Neem leaf extract are much faster than those observed by us in earlier studies using microorganisms such as fungi, highlighting the possibility that nanoparticle biological synthesis methodologies will achieve rates of synthesis comparable to those of chemical methods.
Abstract: We report on the use of Neem (Azadirachta indica) leaf broth in the extracellular synthesis of pure metallic silver and gold nanoparticles and bimetallic Au/Ag nanoparticles. On treatment of aqueous solutions of silver nitrate and chloroauric acid with Neem leaf extract, the rapid formation of stable silver and gold nanoparticles at high concentrations is observed to occur. The silver and gold nanoparticles are polydisperse, with a large percentage of gold particles exhibiting an interesting flat, platelike morphology. Competitive reduction of Au3+ and Ag+ ions present simultaneously in solution during exposure to Neem leaf extract leads to the synthesis of bimetallic Au core-Ag shell nanoparticles in solution. Transmission electron microscopy revealed that the silver nanoparticles are adsorbed onto the gold nanoparticles, forming a core-shell structure. The rates of reduction of the metal ions by Neem leaf extract are much faster than those observed by us in our earlier studies using microorganisms such as fungi, highlighting the possibility that nanoparticle biological synthesis methodologies will achieve rates of synthesis comparable to those of chemical methods.
2,081 citations
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