Metallo-β-Lactamases: the Quiet before the Storm?
Citations
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Cites background from "Metallo-β-Lactamases: the Quiet bef..."
...VIM-2 has the dubious distinction of being the most-reported metallo- -lactamase worldwide (224)....
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...The metallo- -lactamases have been thoroughly reviewed recently (221, 224), and so this section serves as a summary and epidemiological update....
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...Amino acid sequence identities are as low as 23% across the metallo- -lactamases, including enzymes such as CcrA, CphA, and L1 (Table 1) (182, 224)....
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2,144 citations
Cites background or result from "Metallo-β-Lactamases: the Quiet bef..."
...coli TOP10 and J53 compared with those for strains with the other cloned MBL genes (31, 41)....
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...These include blaIMP, blaVIM, blaGIM, blaSIM, and blaKMH (41)....
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2,044 citations
Cites background or methods or result from "Metallo-β-Lactamases: the Quiet bef..."
...Endemicity of VIM- and IMP-type enzymes has been reported in Greece, Taiwan, and Japan (2,12), although outbreaks and single reports of VIM and IMP producers have been reported in many other countries (Figure 3)....
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...The Etest MBL, using imipenem and imipenem/EDTA, is effi cient for detection of MBL producers with high resistance (12), but may be defi cient for detecting MBL producers with low resistance to imipenem....
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...These enzymes hydrolyze all β-lactams except aztreonam (12)....
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...The Etest MBL strip (bioMérieux, Solna, Sweden) is one of the methods advocated for detecting MBL producers on the basis of inhibition of MBL activity by EDTA (12)....
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...Class B Metallo-β-Lactamases Class B metallo-β-lactamases (MBLs) are mostly of the Verona integron–encoded metallo-β-lactamase (VIM) and IMP types and, more recently, of the New Delhi metalloβ-lactamase-1 (NDM-1) type (2,12)....
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References
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Additional excerpts
...terium was exposed to fluoroquinolones (9, 67)....
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