Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity.
Roberto Romero,Offer Erez,Offer Erez,Offer Erez,Maik Hüttemann,Eli Maymon,Eli Maymon,Eli Maymon,Bogdan Panaitescu,Agustin Conde-Agudelo,Percy Pacora,Percy Pacora,Bo Hyun Yoon,Lawrence I. Grossman +13 more
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TLDR
The mechanisms by which metformin may prevent preeclampsia include a reduction in the production of antiangiogenic factors and the improvement of endothelial dysfunction, probably through an effect on the mitochondria.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2017-09-01 and is currently open access. It has received 168 citations till now. The article focuses on the topics: Metformin & Prediabetes.read more
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Gut microbiome and aging: Physiological and mechanistic insights
Ravinder Nagpal,Rabina Mainali,Shokouh Ahmadi,Shokouh Ahmadi,Shaohua Wang,Ria Singh,Kylie Kavanagh,Dalane W. Kitzman,Almagul Kushugulova,Francesco Marotta,Hariom Yadav +10 more
TL;DR: The present review summarizes the evidences related to the age-associated changes in intestinal microbiota and vice-versa, mechanisms involved in this bi-directional relationship, and the prospective for development of microbiota-based interventions such as probiotics for healthy aging.
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Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association
Nisha I. Parikh,Juan M. Gonzalez,Cheryl A.M. Anderson,Suzanne E. Judd,Kathryn M. Rexrode,Mark A. Hlatky,Erica P. Gunderson,Jennifer J. Stuart,Dhananjay Vaidya,Vascular Biology +9 more
TL;DR: In this article, adverse pregnancy outcomes (APO) such as hypertensive disorders of pregnancy, preterm delivery, gestational diabetes, small-forgestational-age delivery, placental abruption, and pregnancy loss increase a woman's risk of developing cardiovascular disease (CVD) risk factors and of developing subsequent CVD (including fatal and nonfatal coronary heart disease, stroke, peripheral vascular disease, and heart failure).
Journal ArticleDOI
Metformin in cancer.
TL;DR: A number of large scale observational and cohort studies suggest metformin is associated with a reduced risk of a number of cancers, although the data is not conclusive.
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Metformin in COVID-19: A possible role beyond diabetes.
TL;DR: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.
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Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation.
Silvina Beatriz Meroni,Maria Noel Lujan Galardo,Gustavo Marcelo Rindone,Agostina Gorga,Maria Fernanda Riera,Selva B. Cigorraga +5 more
TL;DR: The comprehension of how the final number of Sertoli cells in adulthood is established constitutes a pre-requisite to understand the underlying causes responsible for the progressive decrease in sperm production that has been observed during the last 50 years in humans.
References
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Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C. Knowler,Elizabeth Barrett-Connor,Sarah E. Fowler,Richard F. Hamman,John M. Lachin,Elizabeth A. Walker,David M. Nathan +6 more
TL;DR: In this paper, the authors compared a lifestyle intervention with metformin to prevent or delay the development of Type 2 diabetes in nondiabetic individuals. And they found that the lifestyle intervention was significantly more effective than the medication.
Journal Article
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
R C Turner,Rury R. Holman,Irene M Stratton,Carole A. Cull,David R Matthews,Susan E. Manley,V Frighi,D Wright,Andrew Neil,E M Kohner,H McElroy,C Fox,D R Hadden,Grp Ukpds. +13 more
TL;DR: Since intensive glucose control with metformin appears to decrease the risk of diabetes-related endpoints in overweight diabetic patients, and is associated with less weight gain and fewer hypoglycaemic attacks than are insulin and sulphonylureas, it may be the first-line pharmacological therapy of choice in these patients.
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Role of AMP-activated protein kinase in mechanism of metformin action
Gaochao Zhou,Robert W. Myers,Ying Li,Yuli Chen,Xiaolan Shen,Judy Fenyk-Melody,Margaret Wu,John Ventre,Thomas W. Doebber,Nobuharu Fujii,Nicolas Musi,Michael F. Hirshman,Laurie J. Goodyear,David E. Moller +13 more
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
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Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European Association for the Study of Diabetes
David M. Nathan,John B. Buse,Mayer B. Davidson,Ele Ferrannini,Rury R. Holman,Robert S. Sherwin,Bernard Zinman +6 more
TL;DR: This revision of the consensus algorithm for the medical management of type 2 diabetes focuses on the new classes of medications that now have more clinical data and experience and addresses safety issues surrounding the thiazolidinediones.