Patent•
Method for preparing diaryl ketone from aryl sulfonate
23 Nov 2016-
TL;DR: In this article, a method for preparing diaryl ketone from aryl sulfonate is described. Butler et al. showed that the mixture of carbon monoxide and carbon dioxide can yield high yield, and the reaction conditions are milk, functional groups are high in tolerance, and a substrate is cheap and easy to get.
Abstract: The invention discloses a method for preparing diaryl ketone from aryl sulfonate. The method includes following steps: in the presence of a catalyst and carbon monoxide, allowing aryl sulfonate and aryl boronic acid to react in an organic solvent; after reaction is finished, performing aftertreatment to obtain diaryl ketone. Aryl sufonate is adopted as an electrophilic reagent for Suzuki cross carbonylation coupling reaction, diaryl ketone is directly synthesized through carbon monoxide, aryl sulfonate and aryl boronic acid, reaction conditions are milk, functional groups are high in tolerance, a substrate is cheap and easy to get, and diaryl ketone can be prepared with high yield.
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Patent•
11 Aug 2017
TL;DR: In this paper, a synthesis of a diarylketone derivative is described, which comprises the following steps: adding aryl halide, boronic acid, trichloromethane, an iron-containing catalyst, an inorganic base, an activator and a solvent into a reaction container, and stirring and reacting above substances at 100 -180 DEG C for 12-15 h; diluting the obtained product with water after the above reaction is finished, carrying out ethyl acetate extraction three times, mixing obtained organic phases, and carrying out rot
Abstract: The invention relates to a synthesis technology of a diarylketone derivative. The technology comprises the following steps: adding aryl halide, aryl boronic acid, trichloromethane, an iron-containing catalyst, an inorganic base, an activator and a solvent into a reaction container, and stirring and reacting above substances at 100 -180 DEG C for 12-15 h; diluting the obtained product with water after the above reaction is finished, carrying out ethyl acetate extraction three times, mixing obtained organic phases, and carrying out rotary evaporation to obtain a crude product; and carrying out petroleum ether/ether column chromatography on the crude product to obtain the purified diarylketone derivative. The technology has the advantages of mild technologic conditions, no dangerous gases or solvents, high reaction selectivity and high product yield, and is suitable for being promoted and used.
1 citations
Patent•
24 Nov 2017
TL;DR: In this article, the alpha, beta-diphenyl-1-aryl-acrylketone compound with structure was obtained through ring-opening reaction of cycolpropenone in the presence of a palladium catalyst.
Abstract: The invention belongs to the technical field of organic compound synthesis and particularly relates to a preparation method of an alpha, beta-diphenyl-1-aryl-acrylketone compound. According to the preparation method, in an organic solvent, diphenylcyclopropenone with structure as shown in a formula (I) and arylboronic acid with structure as shown in a formula (II) are taken as reaction materials, and the alpha, beta-diphenyl-1-aryl-acrylketone compound with structure as shown in a formula (III) is obtained through ring-opening reaction of cycolpropenone in the presence of a palladium catalyst; and in the formula (II) and the formula (III), R is independently selected from one of H, methyl, chlorine, trifluoromethyl, phenoxy, vinyl, fluorine, a formyl group, isopropyl, n-propyl, cyan, tertiary butyl, nitro or phenyl.