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Method for rapidly introducing function ions on surface of titanium alloy

TL;DR: In this article, a method for rapidly introducing function ions on the surface of titanium alloy was proposed, which belongs to the technical field of Titanium Alloy medical plant material surface functionalization modified treatment.
Abstract: The invention discloses a method for rapidly introducing function ions on the surface of titanium alloy, and belongs to the technical field of titanium alloy medical plant material surface functionalization modified treatment. The method comprises the steps that firstly, TC4 is adopted as an electrolytic anode, an electrolytic cell is adopted as an electrolytic cathode, and a volcano shaped porouscoating is formed on the surface of a TC4 sample through the plasma high temperature and high pressure transient sintering effect; then, a hydrothermal reaction method is used for introducing function ions into the coating, and meanwhile, the hydrophilicity is improved. The various function ions are evenly distributed on the surface of titanium alloy, and the adhesion and proliferation capabilityof osteogenesis cells is improved. According to the method, the coating can be prepared on the surface of the titanium alloy conveniently and rapidly, the ingredient of a solution is regulated in thefollow-up hydrothermal process, the function ions of Cu, Zn, Mg, Ce, Sr and the like are introduced to the surface of the coating, antibacterial or osteogenesis and other performances of a biologicalmedical metal material are improved, and the good application prospect is achieved in the fields of surface modification of medical implant materials and the like.
Citations
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Patent
30 Aug 2019
TL;DR: In this paper, a nitrogen-doped titanium oxide coating and a preparation method and application thereof are described. But they do not describe the application of the coating in the real world, only in a simulation.
Abstract: The invention relates to a nitrogen-doped titanium oxide coating and a preparation method and application thereof. The nitrogen-doped titanium oxide coating has a porous structure, and the doping quantity of nitrogen elements is 0.5 at%-10at%.

2 citations

Patent
12 Feb 2021
TL;DR: In this article, a method for improving the biological activity of a titanium alloy material, the titanium alloy materials and application is presented, which is applicable to the field of biomedical materials.
Abstract: The invention is applicable to the field of biomedical materials, and provides a method for improving the biological activity of a titanium alloy material, the titanium alloy material and application.The method comprises the following steps: preprocessing a titanium alloy material; and injecting the temperature-sensitive collagen doped with the bone morphogenetic protein 9 into pores of the preprocessed titanium alloy material, wherein the titanium alloy material is a 3D printed porous titanium alloy material. The temperature-sensitive collagen doped with the bone morphogenetic protein 9 is implanted into pores and the surface of the 3D printing porous titanium alloy material, the temperature-sensitive collagen is used as a carrier for providing controlled release of the bone morphogeneticprotein 9, the biological activity of the surface of the titanium alloy material can be enhanced, and the bone ingrowth and osseointegration capacity of the titanium alloy material can be effectivelyimproved.
Patent
Liu Hanyuan, Yu Sen, Hu Rui, Shen Qi, Liu Shaohui 
20 Nov 2020
TL;DR: In this paper, a preparation method of a graphene oxide composited titanium-based medical material is described, which comprises the following steps: (1) putting graphene oxide into deionized water or ethanol, carrying out ultrasonic treatment, and carrying out freeze drying, so as to obtain graphene oxide powder; (2) carrying out ball milling on the graphene oxide and titanium based powder, to obtain mixed powder, and 3D printing on the mixed powder to obtain a porous composite material, and (4) forming micro-nano holes in the surface of the porous composite
Abstract: The invention discloses a preparation method of a graphene oxide composited titanium-based medical material. The preparation method comprises the following steps: (1) putting graphene oxide into deionized water or ethanol, carrying out ultrasonic treatment, and carrying out freeze drying, so as to obtain graphene oxide powder; (2) carrying out ball milling on the graphene oxide powder and titanium-based powder, so as to obtain mixed powder, (3) carrying out 3D printing on the mixed powder, so as to obtain a porous composite material; (4) carrying out stress relief annealing on the porous composite material; and (5) forming micro-nano holes in the surface of the porous composite material, so as to obtain the graphene oxide composited titanium-based medical material. By introducing the graphene oxide, the excellent mechanical properties of the graphene oxide composited titanium-based medical material are guaranteed, and by forming the micro-nano holes, rapid synostosis is generated between the graphene oxide composited titanium-based medical material and peripheral bone tissues, so that the applicability of the graphene oxide composited titanium-based medical material is improved.
Patent
15 Dec 2020
TL;DR: In this article, a functional coating for a medical metal surface and a preparation method for the functional coating is described. But the preparation process is simple, convenient and economical; the function of the coating is stable and has an outstanding effect, and can be suitable for surface modification of medical metal and alloy implants.
Abstract: The invention relates to a long-acting infection resisting and high-efficiency osseointegration promoting functional coating for a medical metal surface and a preparation method for the functional coating. According to the functional coating, multifunctional physiologically essential metal ions, inorganic acid radical ions and the like are subjected to ion exchange and modification with inorganicsalts on nano-fibers and the nano-pore wall of the medical metal surface; then, the medical metal surface is placed in a bionic physiological solution for a mineralization reaction; calcium phosphatecoatings similar to a bone mineral chemical composition and distributed in different granularity gradients are deposited in nano-pores, nano-fiber gaps and the upper surface of a fiber layer, and themineralized coatings effectively adjust long-acting release of the functional ions deposited on the nano-fibers, and enhances the integration efficiency and the bonding strength with bones, so that properties of long-acting infection resisting and osseointegration firming are obtained. The preparation process for the coating is simple, convenient and economical; the function of the coating is stable and has an outstanding effect, and can be suitable for surface modification of medical metal and alloy implants, which need to be permanently integrated with bones, including orthopedic implant prostheses, oral implants and the like.
References
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Patent
31 Mar 2005
TL;DR: In this article, an Osseo-inductive metal implant for a living body and the producing method thereof and, more particularly, the producing process of the metal implant is described by forming, on the surface of a metal implant, the layer of metal oxide and the layer injected with bioactive material.
Abstract: This invention provides an Osseo-inductive metal implant for a living body and the producing method thereof and, more particularly, the Osseo-inductive metal implant for a living body according to the present invention is produced by forming, on the surface of the metal implant, the layer of metal oxide and the layer of bio-active material injected.

23 citations

Patent
21 Dec 2009
TL;DR: A hydrothermal process for making Alpha Alumina ((α-AI 2 O 3 ) crystalline nano-sized powders in the form of at least one of nano-sheets and nano-fibers is described in this article.
Abstract: A hydrothermal process for making Alpha Alumina ((α-AI 2 O 3 ) crystalline nano-sized powders in the form of at least one of nano-sheets and nano-fibers, the process includes making the Alpha Alumina with an aspect ratio of diameter to thickness ratio of at least two, and with at least one dimension of diameter or thickness being less than 100 nm. A composition in accordance with the process. A porous ceramic that includes the composition.

13 citations

Journal ArticleDOI
TL;DR: In this paper, the authors show that effective and fast osseointegration is significantly affected by the topographic features and chemical compositions of titanium-based orthopedic implants.
Abstract: Effective and fast osseointegration is significantly affected by the topographic features and chemical compositions of titanium (Ti)-based orthopedic implants. In this study, strontium (Sr) ions fu...

12 citations

Patent
06 Feb 2013
TL;DR: In this article, the authors proposed a preparation method for medical titanium with a trace element slow-release function or a titanium alloy implant material as well as an application of the medical titanium.
Abstract: The invention relates to medical titanium with a trace element slow-release function or a titanium alloy implant material as well as a preparation method and an application of the medical titanium. The invention adopts the technical scheme that the preparation method comprises the following steps: putting a polished titanium-containing metal sheet into an electrolyte as an anode for anodic oxidation; flushing and drying the titanium-containing metal sheet subjected to anodic oxidation, carrying out heat treatment for 1-3 hours at a temperature of 100-500 DEG C, naturally cooling and ultrasonically cleaning and drying; and putting the dried titanium-containing metal sheet into one of or mixed solution of more than any two strontium hydroxide, strontium acetate, zinc acetate or magnesium acetate, carrying out hydrothermal reaction for 0.5-12 hours in a closed container at a temperature of 100-300 DEG C, naturally cooling, taking out, cleaning and drying, and carrying out heat treatment for 1-3 hours at a temperature of 450-550 DEG C to obtain the medical titanium with the trace element slow-release function or the titanium alloy implant material. The medical titanium or the titanium alloy implant material as well as the preparation method and the application thereof have the beneficial effects that the preparation method is simple and reliable, the loading quantity and the release amount of trace elements of the medical titanium in a nano tube are controllable, the medical titanium and the biological activity on the alloy surface can be better promoted, and the application prospect is good in the medical implant material.

10 citations

Patent
24 Oct 2012
TL;DR: In this paper, a method of preparing a magnesium-doped hydroxyapatite/titania active film on the surface of medical titanium alloy was described, which has a porous structure, high binding strength with a titanium alloy substrate and good biological activity.
Abstract: The invention discloses a method of preparing a magnesium-doped hydroxyapatite/titania active film on the surface of medical titanium alloy. According to the invention, the technology of microarc oxidation is used for synthesis of the magnesium-doped hydroxyapatite/titania active film on the surface of titanium alloy in phosphate electrolyte containing magnesium ions and calcium ions. The film prepared by using the preparation method provided by the invention has a porous structure, high binding strength with a titanium alloy substrate and good biological activity and cellular affinity.

10 citations