Methods of Investigating and Preparing Inclusion Compounds
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...While it is possible to use both guest or host changes to generate equi- librium constants, guest properties are usually most easily assessed....
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...Additive properties that can be titrated in this way to provide information on theK-values include[32] aqueous solubility [33–35], chemical reactivity[36,37], molar absorptivity and other optical properties (e.g. optical rotation dispersion), phase solubility measurements[38], nuclear magnetic…...
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...drug– CD) interaction, and NMR, which can be used to determine the value of the stability constants (such as K1:1) and gives at the same time the solution geometry of the complexes.([20,40]) CDs and their complexes tend to self-associate in aqueous solutions to formaggregates and the aggregate formation is concentration dependent, increasing with increasing CD concentration....
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...Properties that can be titrated in this way include aqueous solubility, chemical reactivity (stability), molar absorptivity, NMR chemical shifts, pKa values and HPLC retention times.([6,20,40]) It is also possible to titrate changes in the physicochemical properties of the host molecule (i....
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...Various methods can be applied to prepare D/CD complexes, including the solution method, the co-precipitation method, neutralisation method, the slurry method, the kneading method and the grinding method [23,32]....
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...In theory, any methodology that can be used to observe these changes in additive physicochemical properties may be utilised to determine the stoichiometry of the complexes formed and the numerical values of their stability constants [23-25]....
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