Methyl 2‐benzoylamino‐3‐dimethylaminopropenoate in the synthesis of heterocyclic systems. An attempt to prepare benzoylamino substituted azolo‐ and azinopyrimidines with a bridgehead nitrogen atom
TL;DR: Methyl 2-benzoylamino-3-dimethylaminopropenoate (2) was introduced as a new reagent for the preparartion of fused pyrimidinones 4 from heterocyclic α-amino compounds in acetic acid as mentioned in this paper.
About: This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-02-01. It has received 25 citations till now. The article focuses on the topics: Pyridazine & Bicyclic molecule.
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TL;DR: The formation of 1,2,4-triazolo [1,5-a] pyrimidines (TPs) was first reported by Biilow and Haas.
Abstract: Publisher Summary The formation of 1,2,4-triazolo [1,5-a] pyrimidines (TPs) was first reported by Biilow and Haas Over the next 50 years, only a few papers and patents on TPs were published, which were included in Mosby's comprehensive monograph on “Heterocyclic Systems with Bridgehead Nitrogen Atoms” Most syntheses of TPs start either from a 1,2,4-triazole derivative or from a pyrimidine residue and need annulation of a second heterocyclic ring Preferably 5-amino-1,2,4-triazoles (AT) and 2-hydrazinopyrimidines (HP) are used as starting synthons In the synthesis of TPs from HPs, intermediates are believed to exist and have been isolated in many cases These products and other acylated HPs may serve as convenient starting materials for cyclization reactions Acylated HPs are also prepared from 2-alkylthiopyrimidines and acylhydrazines and, further, cyclized in situ to triazolopyrimidines Many TPs have been tested as potential growth inhibitors of microorganisms, because they are isomeric to purines and in some cases can be converted to nucleoside analogs
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39 citations
TL;DR: In this article, a method for the preparation of condensed pyranones is presented. But the method is not suitable for the extraction of condensed Pyranone derivatives, such as barbituric acid derivatives, pyrazolones and resorcinol.
28 citations
TL;DR: In this article, a general method for the preparation of β-heteroarylamino-α, β-dehydro-α-amino acids and dipeptides is described.
26 citations
TL;DR: The β-heteroarylaminomethyleneoxazolones as mentioned in this paper were obtained from heterogeneous formamidines and obtained by catalytic hydrogenation the compounds were converted into βhetero-arylamino substituted amides.
24 citations
TL;DR: In this paper, a simple one-step synthesis of substituted methyl 2-benzolamino-3-anilinopropenoates 8a-r from substituted anilines 7a r and methyl 2.benzoylamino3-dimethylamin-opropoenates 6 is described.
Abstract: A simple one-step synthesis of substituted methyl 2-benzolamino-3-anilinopropenoates 8a-r from substituted anilines 7a-r and methyl 2-benzoylamino-3-dimethylaminopropenoates 6 is described.
Eine einfache, einstufige Synthese substituierter 2-Benzoylamino-3-arylaminopropensauremethylester, Zwischenprodukte fur die Herstellung substituierter Arylaminoaniline.
Eine einfache, einstufige Synthese der substituierten 2-Benzoylamino-3-arylaminopropensauremethylester 8a-r aus den substituierten Anilin-Derivaten 7a-r und 2-Benzoylamino-3-dimethylaminopropensauremethylester 6 wird beschrieben.
10 citations