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Journal ArticleDOI

Methyl 2‐benzoylamino‐3‐dimethylaminopropenoate in the synthesis of heterocyclic systems. An attempt to prepare benzoylamino substituted azolo‐ and azinopyrimidines with a bridgehead nitrogen atom

01 Feb 1990-Journal of Heterocyclic Chemistry (Wiley)-Vol. 27, Iss: 2, pp 359-361
TL;DR: Methyl 2-benzoylamino-3-dimethylaminopropenoate (2) was introduced as a new reagent for the preparartion of fused pyrimidinones 4 from heterocyclic α-amino compounds in acetic acid as mentioned in this paper.
About: This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-02-01. It has received 25 citations till now. The article focuses on the topics: Pyridazine & Bicyclic molecule.
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Book ChapterDOI
TL;DR: This chapter discusses the physicochemical and spectroscopic properties, syntheses, reactions, and more briefly, the utilization of pyrido[1,2-a]pyrimidines.
Abstract: Publisher Summary Pyrido[1,2-a]pyrimidines represent a simple bicyclic ring system that contains a nitrogen-bridgehead condensed pyrimidine moiety. Synthetic methods for these compounds can often be applied to the preparation of similar bi- and polycyclic ring systems. This chapter covers the primary chemical literature published between the second half of 1981 and 1993 and contained in Chemical Abstract Chemical Substance Indexes, Volumes 95-119 inclusive. The representatives of 4-oxo-4H-pyrido[1,2-a]pyrimidines, which exhibit valuable biological activities, have aroused much interest. Their pharmacological activities have been examined intensively, and the therapeutic effects of some of them have been demonstrated in clinics. Other representatives of 4H-pyrido[1,2-a]pyrimidines are used as photographic sensitizers, catalysts for curing polyisocyanates, or as dyes for acrylic nylon, polyester fibers, and photographic materials. The chapter further discusses the physicochemical and spectroscopic properties, syntheses, reactions, and more briefly, the utilization of pyrido[1,2-a]pyrimidines. It also reviews the pyrido[1,2-a]pyrimidines salts, the 2-oxo-2H-, 4-oxo-4H-, and then the 6-oxo-6H-pyrido[1,2-a]pyrimidines, followed by the 3,4-dihydro-2H-pyrido[1,2-a]pyrimidines, the 2-oxo-3,4-dihydro-2H- and 4-oxo-2,3-dihydro-4H-pyrido[1,2-a]pyrimidines, and finally pyrido[1,2-a]pyrimidines.

16 citations

Journal ArticleDOI
TL;DR: A series of (E )-(2-arylpyrazino[1,2- a ]pyrimidine-4-ylidene) acetonitriles was synthesized in excellent yields through base catalyzed ring transformation of suitably functionalized 2 H -pyran-2-ones 3 using 2-aminopyrazine 4a and arylamidinium salts 4b, separately.

15 citations

Journal ArticleDOI
TL;DR: The pyridine and quinoline derivatives 2, 3, and 6 with an activated methylene group atα-position in respect to the ring nitrogen atom were converted with 1, 8, or 9 into fused pyrido[1,2-a]pyridine derivatives 4, 5, 7, and 10.

13 citations

References
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Journal ArticleDOI
TL;DR: In this article, a method for the preparation of condensed pyranones is presented. But the method is not suitable for the extraction of condensed Pyranone derivatives, such as barbituric acid derivatives, pyrazolones and resorcinol.

28 citations

Journal ArticleDOI
TL;DR: In this article, a general method for the preparation of β-heteroarylamino-α, β-dehydro-α-amino acids and dipeptides is described.

26 citations

Journal ArticleDOI
TL;DR: The β-heteroarylaminomethyleneoxazolones as mentioned in this paper were obtained from heterogeneous formamidines and obtained by catalytic hydrogenation the compounds were converted into βhetero-arylamino substituted amides.

24 citations

Journal ArticleDOI
TL;DR: In this paper, a simple one-step synthesis of substituted methyl 2-benzolamino-3-anilinopropenoates 8a-r from substituted anilines 7a r and methyl 2.benzoylamino3-dimethylamin-opropoenates 6 is described.
Abstract: A simple one-step synthesis of substituted methyl 2-benzolamino-3-anilinopropenoates 8a-r from substituted anilines 7a-r and methyl 2-benzoylamino-3-dimethylaminopropenoates 6 is described. Eine einfache, einstufige Synthese substituierter 2-Benzoylamino-3-arylaminopropensauremethylester, Zwischenprodukte fur die Herstellung substituierter Arylaminoaniline. Eine einfache, einstufige Synthese der substituierten 2-Benzoylamino-3-arylaminopropensauremethylester 8a-r aus den substituierten Anilin-Derivaten 7a-r und 2-Benzoylamino-3-dimethylaminopropensauremethylester 6 wird beschrieben.

10 citations

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