Mice with Spontaneous Pancreatic Cancer Naturally Develop MUC-1-Specific CTLs That Eradicate Tumors When Adoptively Transferred
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Cites background from "Mice with Spontaneous Pancreatic Ca..."
...The CTLs appeared to be effective in eradicating MUC1+ cells in the spontaneous pancreatic tumors, as immunohistochemical analysis of tumors taken at sacrifice showed little MUC1 reactivity, yet the tumors progressed, showing the need for multiple antigens in vaccine strategies (142)....
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...human MUC1 at high levels and show underglycosylation typical of human adenocarcinomas (142)....
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...The CTLs were specific for tumor MUC1 and, when adoptively transferred, killed MUC1-expressing tumor cells derived from mammary gland, pancreas, or melanomas (142)....
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"Mice with Spontaneous Pancreatic Ca..." refers background in this paper
...The tandem repeats (TRs) serve as the scaffold for O-linked oligosaccharides that cover the polypeptide core (6)....
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"Mice with Spontaneous Pancreatic Ca..." refers background in this paper
...Many reports have suggested that progressing tumors in cancer patients have elaborate means of escaping an apparently effective MHC class I-restricted immune response (45, 46)....
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