Book ChapterDOI
Micro-electro-mechanical system–based drug delivery devices
Ankur Gupta,Pramod Kumar Pal +1 more
- pp 183-210
Reads0
Chats0
TLDR
This chapter provides an insight into the basics of various drug delivery devices, their principles, description of various components used in the micro-electro-mechanical system (MEMS) device manufacturing, along with the state-of-the-art review of existing MEMS-based drug Delivery devices.Abstract:
Safe delivery of drugs inside living organism is always a great challenge. Drug intake below and above prescribed limits may cause unseen and severe health problems. In addition to the amount of dose, another critical issue is to deliver drugs inside the body. Preferable drug delivery modes are oral, inhalation, nasal, rectal routes, or via injection. Further, there are situations when a drug has to be released over a specific duration in a controlled mode. In order to have scientific solutions to the problems and challenges faced, researchers have come up with various drug delivery devices. This field has resorted to various micro-fabrication techniques and fluidic principles coupled with the assistance of electrical and mechanical engineering knowledge. It has observed a series of developments in device optimization. These devices have been developed for real-time monitoring and measurement of drug delivery and thus may have several components (micro-pump, micro-needles, microfluidic channels, micro-sensors, essential electronic circuits, and so on). Keeping up with the vast development in the field of drug delivery devices, this chapter provides an insight into the basics of various drug delivery devices, their principles, description of various components used in the micro-electro-mechanical system (MEMS) device manufacturing, along with the state-of-the-art review of existing MEMS-based drug delivery devices.read more
Citations
More filters
Journal ArticleDOI
MEMS actuators for biomedical applications: a review
Farah Afiqa Mohd Ghazali,Nazibul Hasan,Tariq Rehman,Tariq Rehman,Marwan Nafea,Mohamed Sultan Mohamed Ali,Kenichi Takahata +6 more
Journal ArticleDOI
Functional characterization of nano-porous silicate-polymer composite for bovine serum albumin immobilization
TL;DR: In this article, a simple and energy-efficient approach for the bottom-up fabrication of porous polymeric film, which possesses unique surface, structural and bulk properties, followed by its comprehensive study through various characterization techniques.
Journal ArticleDOI
A Chemometric-Assisted Colorimetric-Based Inexpensive Paper Biosensor for Glucose Detection
TL;DR: In this paper , a simple and inexpensive leak-proof paper pad with an initial selection of a paper substrate on the grounds of surface morphology and fluid absorption time was used for glucose detection on a paper pad through colorimetric analysis.
Journal ArticleDOI
Investigation of surface characteristics and effect of electrodeposition parameters on nickel-based composite coating
Prince Kumar Rai,Ankur Gupta +1 more
TL;DR: In this article, the effects of graphite particles on surface morphologies, compositions, and coating thickness were investigated by optical microscopy, SEM, EDS, and XRD.
Journal ArticleDOI
Analysis of interelectrode gap in μEDM and energy dissipation in single discharge: A review
TL;DR: In this paper, a robust model deducing the spark gap in a single discharge in µ-EDM needs to be designed to evaluate various phenomena in the pre-breakdown period, which involves various variables and is highly complicated.
References
More filters
Journal Article
Drug delivery and targeting
TL;DR: When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug safety and efficacy can be greatly improved and new therapies are possible.
Journal ArticleDOI
Microneedles for drug and vaccine delivery.
TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
Journal ArticleDOI
Drug delivery systems: An updated review.
Gaurav Tiwari,Ruchi Tiwari,Birendra Sriwastawa,Lokesh Kumar Bhati,Suyog Pandey,Preeti Pandey,Saurabh K Bannerjee +6 more
TL;DR: Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.
Journal ArticleDOI
Optical biosensors in drug discovery.
TL;DR: Advances in instrumentation and experimental design have led to the increasing application of optical biosensors in many areas of drug discovery, including target identification, ligand fishing, assay development, lead selection, early ADME and manufacturing quality control.
Journal ArticleDOI
Microfluidic Mixing: A Review
TL;DR: A high level overview of the field of microfluidic mixing devices is provided before describing some of the more significant proposals for active and passive mixers.