Microbial natural products: molecular blueprints for antitumor drugs
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Cites background from "Microbial natural products: molecul..."
...A discussion of the probabilities of ET743 and its congeners being produced by as yet uncultured microbes associated with the source tunicate was recently published by Giddings and Newman [28] which should be consulted for further details....
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References
5,170 citations
"Microbial natural products: molecul..." refers background in this paper
...Approximately 50 % of all small molecules that were approved by the FDA between 2000 and 2006 were not the new chemical entities derived from combinatorial chemistry but rather based upon natural products [150]....
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...N natural product, NB natural product botanical (a defined mixture of compounds), ND derived from a natural product; usually a semisynthetic modification, S totally synthetic drug, S* made by total synthesis; pharmacophore from a natural product, NM natural product mimic (sub-category) [150, 152] a Quite different preparations 1184 J Ind Microbiol Biotechnol (2013) 40:1181–1210...
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Additional excerpts
...00/Mbp [187]....
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"Microbial natural products: molecul..." refers background in this paper
...5 %), ND (59; 31 %), S (44; 23 %), S/NM (19; 10 %), S* (20; 11 %), and S*/NM (17; 9 %) [150– 152]....
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...N natural product, NB natural product botanical (a defined mixture of compounds), ND derived from a natural product; usually a semisynthetic modification, S totally synthetic drug, S* made by total synthesis; pharmacophore from a natural product, NM natural product mimic (sub-category) [150, 152] a Quite different preparations J Ind Microbiol Biotechnol...
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