Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases.
Citations
769 citations
Cites background from "Microbiota metabolite short chain f..."
...SCFAs are major anions in the colon, mainly as acetate, propionate, and butyrate [22]....
[...]
584 citations
Cites background from "Microbiota metabolite short chain f..."
...SCFAs were reported to be the major source of nutrition for colonic epithelial cells [98,101], especially butyrate [102,103]....
[...]
561 citations
413 citations
Cites background from "Microbiota metabolite short chain f..."
...Indeed, they have been shown to ameliorate IBD, although their exact mechanism of action is still not completely clear [15]....
[...]
409 citations
References
4,233 citations
3,733 citations
"Microbiota metabolite short chain f..." refers background in this paper
...GPR43 on colonic T cells induces the differentiation and enhances the suppressive function of Foxp3 Tregs through epigenetic modifications [3]....
[...]
...SCFA also enhance Foxp3 expression of colonic T cells via activation of GPR43 on T cells [3]....
[...]
...Importantly, propionate or SCFA mix-treated Rag mice injected with naı̈ve T cells and Treg had lower level of colitis than mice received water [3]....
[...]
3,596 citations
"Microbiota metabolite short chain f..." refers background in this paper
...tone H3 acetylation of Foxp3 and promoted the differentiation of Treg, which acts as a key anti-inflammatory effector [35]....
[...]
...provided with SCFA had an increased number of extrathymic Foxp3 Treg cells [35] and SCFA promoted conversion of naı̈ve T cells toward Treg under Treg-cell polarization condition [36]....
[...]
3,509 citations
"Microbiota metabolite short chain f..." refers background in this paper
...This commensal microbiota not only contributes to the regulation of host immune response and homeostasis, but also participates in the breakdown of food and energy metabolism [9, 10]....
[...]
3,363 citations
"Microbiota metabolite short chain f..." refers background in this paper
...SCFA are the most abundant products derived from commensal bacterial fermentation of indigestible dietary fibers in intestines [14]....
[...]
...C4 is formed from acetyl-CoA and butyryl-CoA, as well as acetate and lactate [14]....
[...]