Microglia During Development and Aging
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...…refinement, where they appear to engulf and remove dendritic spines ‘‘marked’’ for removal by members of the classical complement cascade complement receptor 3 and C1q (Chu et al., 2010; Clarke and Barres, 2013; Harry, 2013; Paolicelli et al., 2011; Stephan et al., 2013; Tremblay et al., 2010)....
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Cites background from "Microglia During Development and Ag..."
...In the CNS, microglia are distributed widely in the gray and white matter, and they present local singularities related to their function (Harry, 2013)....
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...The brain and the retina suffer agerelated deterioration/degeneration (Harry, 2013), and to discover the importance of age in this process, which cannot be avoided or changed, it is paramount to unravel the influence of the other main aetiological elements (for example life-style and environmental factors) on the initiation and progression of neurodegeneration....
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...Microglia colonise CNS structures during embryogenesis and in the early postnatal period until they reach their positions in the mature brain (Harry, 2013)....
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