Microglial activation and its implications in the brain diseases.
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...ctivation results in a transition in microglial morphology to an meboid state facilitating the migration of these cells to the site f insult [41]....
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...Microglial response to CNS pathology also results n initiation of a number of immune functions including phagoytosis, antigen processing and presentation, and production of oth cytotoxic and neurotrophic factors [41,180]....
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703 citations
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...Inflammation and apoptosis Studies of the neuroprotective roles of HDAC inhibitors, which are known to broadly affect gene expression within the immune system, have been extended to other diseases that involve inflammation and neuronal apoptosis, such as multiple sclerosi...
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...However, although activation of microglia is a typical hallmark of brain pathology, the extent to which it has beneficial or detrimental functions in the brain in different psychiatric disorders remains to be elucidated (Dheen et al., 2007)....
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