Fig. 5. Graphic representation of the cross-associations among demographic variables, 838 micronutrient supplementation and microbiota over time. Interconnected arrows indicate the tested 839 cross-correlated paths between nodes of: place of residence (site), supplementation, and the 840 composite measures of bacterial and eukaryotic OTUs detected at 12 and 24 months, collapsed as 841 latent PLS-scores. Negative correlations are indicated in pink and positive in blue. Arrow thickness 842 is weighted by the effect size of the direct path coefficients as indicated in Supplementary Table 843 5. Significance of direct paths, *p < 0.05, **p < 0.01, ***p < 0.0001. OTUs that loaded positively 844 (>0.4) or negatively (<-0.4) within each PLS-score are listed within boxes. PLS, partial least 845 square; OTUs, operational taxonomic units. 846 847 848
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