Journal ArticleDOI
MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2
Anyi Dai,Haixiang Sun,Ting Fang,Qun Zhang,Shaogen Wu,Yue Jiang,Lijun Ding,Guijun Yan,Yali Hu +8 more
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TLDR
It is demonstrated that miR‐133b down‐regulates Foxl2 expression in granulosa cells by directly targeting the 3′UTR, thus inhibiting the Foxl 2‐mediated transcriptional repression of StAR and CYP19A1 to promote estradiol production.About:
This article is published in FEBS Letters.The article was published on 2013-08-02. It has received 101 citations till now. The article focuses on the topics: Granulosa cell & Steroidogenic acute regulatory protein.read more
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Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease.
TL;DR: The involvement of the related myomiRs at the crossroads between cell development/tissues regeneration/tissue inflammation responses, and cancer development is examined.
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FOXL2: a central transcription factor of the ovary.
Adrien Georges,Aurélie Auguste,Laurianne Bessière,Anne Vanet,Anne-Laure Todeschini,Reiner A. Veitia +5 more
TL;DR: A better understanding of the impact of FOXL2 mutations and of the molecular aspects of its function is required to rationalise its implication in various pathophysiological processes.
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MicroRNAs in ovarian follicular atresia and granulosa cell apoptosis
TL;DR: A deep understanding of the roles of miRNA networks will not only help elucidate the mechanisms of GC apoptosis, follicular development, atresia and their disorders but also offer new diagnostic and treatment strategies for infertility and other ovarian dysfunctions.
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MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)
Anja Elaine Sørensen,Marie Louise Muff Wissing,Sofia Salö,Anne Lis Mikkelsen Englund,Louise Torp Dalgaard +4 more
TL;DR: The understanding of miRNAs, particularly in relation to PCOS, is currently at a very early stage, and additional studies will yield important insight into the molecular mechanisms behind this complex and heterogenic syndrome.
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Regulatory role of microRNAs in ovarian function
Tal Imbar,Iris Eisenberg +1 more
TL;DR: Because of microRNAs' known stability in body fluids, their potential use in the clinical setting as novel biomarkers for ovarian function may offer new diagnostic and treatment strategies for infertility and other ovarian disorders.
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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StAR Protein and the Regulation of Steroid Hormone Biosynthesis
TL;DR: The tertiary structure of the START domain of a StAR homolog has been solved, and identification of a cholesterol-binding hydrophobic tunnel within this domain raises the possibility that StAR acts as aolesterol-shuttling protein.
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The biology of infertility: research advances and clinical challenges
Martin M. Matzuk,Dolores J. Lamb +1 more
TL;DR: The past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility, but translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples.