MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
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...Systemic delivery of cholesterol-modified miR-21 antagomirs has been reported to diminish MAPK signaling in cardiac fibroblasts and thereby completely prevent and reverse cardiac dysfunction, fibrosis, and hypertrophy in response to pressure overload (Thum et al., 2008)....
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...Administration of inhibitors that target this miRNA prevent pathologic cardiac remodeling yet germ-line deletion of miR-21 has no effect on cardiovascular pathology (Patrick et al., 2010; Thum et al., 2008)....
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...…class of miRNAs is miR-21, which is upregulated by MAPK/ERK signaling in response to cardiac stress (van Rooij et al., 2006; Patrick et al., 2010; Thum et al., 2008). miR-21 targets Sprouty2 (Spry2), a negative regulator of the MAPK/ERK cascade, thereby further enhancing signaling through this…...
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...Among this class of miRNAs is miR-21, which is upregulated by MAPK/ERK signaling in response to cardiac stress (van Rooij et al., 2006; Patrick et al., 2010; Thum et al., 2008)....
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1,238 citations
Cites background from "MicroRNA-21 contributes to myocardi..."
...Investigators have shown that the ERK-MAP kinase pathway is under control, in CFs, of miR-21 (263)....
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...Most importantly, the pharmacological silencing of miR-21 in vivo by using specific antisense chemistries is able to reduce the activation of the ERK-MAP kinase pathway and, consequently, the onset of fibrosis and hypertrophy following pressure overload (263)....
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References
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