MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
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...In contrast, though, miR-21 enhances cell migration and invasion but not proliferation in androgen-independent cell lines, where it targets myristoylated alanine-rich C kinase substrate (MARKCS) (361)....
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...These include downregulation of miR-34, which is especially reduced in p53-deficient CaP cells, as it is induced by p53 and mediates its apoptotic effects (188, 511); downregulation of miR-330, which suppresses E2F-1 and E2F-1-medited AKT phosphorylation (339); upregulation of miR-20a, which suppresses E2F2 and E2F3 and prevents their excessive accumulation and, thus, apoptosis (590); upregulation of miR-125b, which inhibits the expression of the proapoptotic protein Bak1 (557), in addition, to the upregulation of miR-21, which is an established suppressor of apoptosis (361)....
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...For example, miR-21 upregulation may reduce apoptosis, induce proliferation, and facilitate cell migration [32]....
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