MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer
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TLDR
It is demonstrated that overexpression of miR‐216a/217 acted as a positive feedback regulator for the TGF‐β pathway and the canonical pathway involved in the activation of phosphoinositide 3‐kinase/protein kinase K (PI3K/Akt) signaling in HCC cells.About:
This article is published in Hepatology.The article was published on 2013-08-01 and is currently open access. It has received 344 citations till now. The article focuses on the topics: PTEN & PI3K/AKT/mTOR pathway.read more
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TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
TL;DR: The role of TGF-β signaling in cell cycle arrest, apoptosis, EMT and cancer cell metastasis is considered and recent insights into the multistep and dynamically controlled process of T GF-β-induced EMT are highlighted.
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Non-Smad Signaling Pathways of the TGF-β Family
TL;DR: This review summarizes the current knowledge of the mechanisms by which non-Smad signaling pathways are directly activated in response to ligand binding, how activation of these pathways impinges on Smads and non- Smad targets, and how final cellular responses are affected in Response to these noncanonical signaling modes.
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Role of epithelial to mesenchymal transition in hepatocellular carcinoma
TL;DR: Some aspects of EMT are still elusive and further studies are required to better link the clinical management of HCC with biomarkers and targeted therapies related to EMT, as well as explaining the current limiting insights into EMT by snapshot analyses of H CC tissues.
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The role and mechanisms of action of microRNAs in cancer drug resistance.
TL;DR: A holistic understanding of the functions of miRNAs in drug resistance will help to develop better strategies to regulate them efficiently and will finally pave the way toward better translation of miRNA into clinics, developing them into a promising approach in cancer therapy.
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Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways.
TL;DR: This review discusses recent progress in the understanding of the cross talk between Smad proteins and signaling pathways of Wnt, Notch, Hippo, Hedgehog, mitogen-activated protein (MAP), kinase, phosphoinositide 3-kinase (PI3K)-Akt, nuclear factor κB (NF-κB), and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways.
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
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Management of hepatocellular carcinoma: An update
Jordi Bruix,Morris Sherman +1 more
TL;DR: The American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) were updated in 2010 as discussed by the authors.
AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update
Jordi Bruix,Morris Sherman +1 more
TL;DR: Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated.
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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
TL;DR: This review will provide potential mechanistic explanations for the association between EMT induction and the emergence of CSCs, and highlight recent studies implicating the function of TGF-β-regulated noncoding RNAs in driving EMT and promoting CSC self-renewal.
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