Journal ArticleDOI
MicroRNAs and Malaria - A Dynamic Interaction Still Incompletely Understood.
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TLDR
The role of microRNA in the pathogenesis of severe malaria remains incompletely understood, hindering our ability to treat this disease as discussed by the authors, and the role of small, non-coding RNAs play in the progression, pathogenesis, and resistance to, malaria.Abstract:
Malaria is a mosquito-borne infectious disease caused by parasitic protozoa of the genus Plasmodium. It remains a major problem affecting humans today, especially children. However, the pathogenesis of malaria, especially severe malaria, remains incompletely understood, hindering our ability to treat this disease. Of recent interest is the role that small, non-coding RNAs play in the progression, pathogenesis of, and resistance to, malaria. Independent studies have now revealed the presence of microRNA (miRNA) in the malaria parasite, vector, and host, though these studies are relatively few. Here, we review these studies, focusing on the roles specific miRNA have in the disease, and how they may be harnessed for therapeutic purposes.read more
Citations
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Journal ArticleDOI
Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria.
Mohamed A. Dkhil,Mohamed A. Dkhil,Saleh Al-Quraishy,Abdel-Azeem S. Abdel-Baki,Abdel-Azeem S. Abdel-Baki,Denis Delic,Frank Wunderlich +6 more
TL;DR: Investigation of possible effects of both protective vaccination and P. chabaudi malaria on the miRNome of the liver as an effector against blood-stage malaria using miRNA microarrays and quantitative PCR finds liver regeneration is accelerated as suggested by upregulation.
Journal ArticleDOI
Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review.
Gregorio Rangel,Nattawat Teerawattanapong,Supat Chamnanchanunt,Tsukuru Umemura,Anuwat Pinyachat,Surasak Wanram +5 more
TL;DR: It was found that malaria parasite infected liver or tissue produce tissue-specific miRNAs and release to the blood stream, indicating the potential use of those mi RNAs as biomarkers for malaria infection.
Journal ArticleDOI
MicroRNAs: master regulators in host–parasitic protist interactions
Maura Rojas-Pirela,Diego Andrade-Alviarez,Lisvaneth Medina,Christian Castillo,Ana Liempi,Jesús Guerrero-Muñoz,Yessica Ortega,Juan Diego Maya,Verónica Rojas,Wilfredo Quiñones,Paul A.M. Michels,Ulrike Kemmerling +11 more
TL;DR: The present review is focused on the possible role of miRNAs in the pathogenesis of diseases of clinical interest caused by parasitic protists, and the potential role ofmiRNAs as targets for the design of drugs and diagnostic and prognostic markers of parasitic diseases is discussed.
Journal ArticleDOI
Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection
Wilhelm Bertrams,Kathrin Griss,M Han,Kerstin Seidel,Stefan Hippenstiel,Norbert Suttorp,Florian Finkernagel,Jochen Wilhelm,Claus Vogelmeier,Bernd Schmeck,Bernd Schmeck +10 more
TL;DR: This article identified transcripts from patient leukocytes that differentiate between healthy, Malaria and community-acquired pneumonia (CAP) patients, and established discriminating transcriptomic features versus Malaria by principal component (PCA) and receiving operator characteristic (ROC) analyses and in silico cell type deconvolution.
Journal ArticleDOI
"Dual-gene" malaria-resistance: Therapeutically-rational exchange (T-REX) of group-O sickle trait and group-O C-traittrait red blood cells can be evaluated in Benin and Nigeria.
TL;DR: It is prudent to assume - until proven otherwise - that T-REX of "dual-gene" malaria-resistant RBCs can improve ("personalize") rescue of these patient subsets of Pf-malaria patients.
References
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Journal ArticleDOI
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The Liver as a Lymphoid Organ
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