MicroRNAs and ovarian function
Citations
247 citations
Cites background from "MicroRNAs and ovarian function"
...During the dynamic phase of follicular development and oocyte maturation, miRNAs play an important role by coordinating the expression of genes in a spatial and temporal specific manner [21,22]....
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178 citations
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101 citations
Cites background from "MicroRNAs and ovarian function"
...The effects of miRNAs on ovarian function primarily occur through their actions on somatic cells, such as granulosa cells [12]....
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97 citations
Cites background from "MicroRNAs and ovarian function"
...Folliculogenesis and steroidogenesis are complex processes involving intraovarian gene expression, signaling pathways, and endocrine and paracrine factors [8, 9]....
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...In each stage of follicle development, different growth factors contribute to stage-specific functions in different cell types [8, 9]....
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References
32,946 citations
"MicroRNAs and ovarian function" refers background in this paper
...The genes that encode miRNAs, which comprise a class of naturally occurring, small non-coding RNAs, are generally transcribed by RNA polymerase II, processed into short hairpin RNAs by the enzyme Drosha and its RNA-binding cofactor DiGeorge syndrome critical region gene 8 (DGCR8), as shown in Figure 1 [4-7]....
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15,374 citations
"MicroRNAs and ovarian function" refers background in this paper
...MicroRNAs (miRNAs) are small (19-25 bp) RNAs that diversely regulate gene expression through their decrease of messenger RNA (mRNA) stability or translation [1-3]....
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11,624 citations
"MicroRNAs and ovarian function" refers background in this paper
...It has been estimated that 30-90% of messenger RNAs may be subjected to miRNA regulation, and individual miRNAs are predicted to target up to several hundred genes [14-16]....
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5,791 citations
"MicroRNAs and ovarian function" refers background in this paper
...In addition, miRNAs may also increase translation of specific mRNAs in a manner dependent on the cell cycle [25], and a large number of miRNAs may be expressed in a tissue-specific manner [26]....
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4,490 citations
"MicroRNAs and ovarian function" refers background in this paper
...Recognition is thought to mainly involve base pairing of miRNA nucleotides 2-8, representing the seed sequence [13]....
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