MicroRNAs and ovarian function
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Additional excerpts
...与真核生物的生殖、发育、病毒防御、细胞增殖和 凋亡、脂肪代谢等多种生命活动([1-4])。MiR-143 为一 种广泛性表达的 miRNA,可在不同物种的许多组织 器官以及特定细胞中检测到它的表达。研究表明其...
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References
32,946 citations
"MicroRNAs and ovarian function" refers background in this paper
...The genes that encode miRNAs, which comprise a class of naturally occurring, small non-coding RNAs, are generally transcribed by RNA polymerase II, processed into short hairpin RNAs by the enzyme Drosha and its RNA-binding cofactor DiGeorge syndrome critical region gene 8 (DGCR8), as shown in Figure 1 [4-7]....
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15,374 citations
"MicroRNAs and ovarian function" refers background in this paper
...MicroRNAs (miRNAs) are small (19-25 bp) RNAs that diversely regulate gene expression through their decrease of messenger RNA (mRNA) stability or translation [1-3]....
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11,624 citations
"MicroRNAs and ovarian function" refers background in this paper
...It has been estimated that 30-90% of messenger RNAs may be subjected to miRNA regulation, and individual miRNAs are predicted to target up to several hundred genes [14-16]....
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5,791 citations
"MicroRNAs and ovarian function" refers background in this paper
...In addition, miRNAs may also increase translation of specific mRNAs in a manner dependent on the cell cycle [25], and a large number of miRNAs may be expressed in a tissue-specific manner [26]....
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4,490 citations
"MicroRNAs and ovarian function" refers background in this paper
...Recognition is thought to mainly involve base pairing of miRNA nucleotides 2-8, representing the seed sequence [13]....
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