MicroRNAs and ovarian function
Citations
247 citations
Cites background from "MicroRNAs and ovarian function"
...During the dynamic phase of follicular development and oocyte maturation, miRNAs play an important role by coordinating the expression of genes in a spatial and temporal specific manner [21,22]....
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178 citations
110 citations
101 citations
Cites background from "MicroRNAs and ovarian function"
...The effects of miRNAs on ovarian function primarily occur through their actions on somatic cells, such as granulosa cells [12]....
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97 citations
Cites background from "MicroRNAs and ovarian function"
...Folliculogenesis and steroidogenesis are complex processes involving intraovarian gene expression, signaling pathways, and endocrine and paracrine factors [8, 9]....
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...In each stage of follicle development, different growth factors contribute to stage-specific functions in different cell types [8, 9]....
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References
341 citations
"MicroRNAs and ovarian function" refers background in this paper
...Examples of these FSH regulated genes include insulin like growth factor binding protein 3 (IGFBP3), steroidogenic acute regulatory protein (StAR), as well as numerous bone morphogenetic proteins (BMPs) [48-51]....
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322 citations
"MicroRNAs and ovarian function" refers background in this paper
...Interestingly, a lack of miR17-5p and let7b, resulted in corpus luteum insufficiency and infertility in mice, and the phenotype was partially reversed by injection of miR17-5p and let7b into the ovaries in the mice [32], indicating the role of these miRNAs in corpus luteum formation....
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...The role of small RNA in the ovary is indicated by the fact that knockout of Dicer, the ribonuclease III which processes pre-small RNA to mature functional small RNA in the ovary resulted in the dysfunction of folliculogenesis, oocyte maturation, ovulation and infertility [30-34]....
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313 citations
"MicroRNAs and ovarian function" refers background in this paper
...Generally, mirtrons compose only a small percentage of genomically encoded miRNAs, as the sequences of mirtrons are not evolutionarily conserved [10]....
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262 citations
"MicroRNAs and ovarian function" refers background in this paper
...In another study, miR-224 was identified as one of 16 transforming growth factorb1 (TGF-b1) regulated miRNAs in cultured murine granulosa cells, regulating granulosa cell proliferation via targeting Smad family member 4 (Smad4) in the TGF-b1 signal transduction pathway [53]....
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255 citations
"MicroRNAs and ovarian function" refers background in this paper
...The role of small RNA in the ovary is indicated by the fact that knockout of Dicer, the ribonuclease III which processes pre-small RNA to mature functional small RNA in the ovary resulted in the dysfunction of folliculogenesis, oocyte maturation, ovulation and infertility [30-34]....
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