MicroRNAs in Stress Signaling and Human Disease
Joshua T. Mendell,Eric N. Olson +1 more
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TLDR
Emerging principles of miRNA regulation of stress signaling pathways are reviewed and applied to the authors' understanding of the roles of miRNAs in disease.About:
This article is published in Cell.The article was published on 2012-03-16 and is currently open access. It has received 1491 citations till now.read more
Citations
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U1 snRNP regulates cancer cell migration and invasion in vitro
Jung-Min Oh,Christopher C. Venters,Chao Di,Anna Maria Pinto,Lili Wan,Ihab Younis,Zhiqiang Cai,Chie Arai,Byung Ran So,Jingqi Duan,Gideon Dreyfuss +10 more
TL;DR: An unexpected role for U1 homeostasis (available U1 relative to transcription) in oncogenic and activated cell states is revealed, and U1 is suggested as a potential target for their modulation.
Posted ContentDOI
U1 snRNP regulates cancer cell migration and invasion
Jung-Min Oh,Christopher C. Venters,Chao Di,Anna Maria Pinto,Lili Wan,Ihab Younis,Zhiqiang Cai,Chie Arai,Byung Ran So,Gideon Dreyfuss +9 more
TL;DR: It is shown that U1 AMO also modulates cancer cells’ phenotype, dose-dependently increasing migration and invasion in vitro by up to 500%, whereas U1 over-expression has the opposite effect.
Journal ArticleDOI
MicroRNA biogenesis pathways in cancer
Shuibin Lin,Richard I. Gregory +1 more
TL;DR: Global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic, highlighting the importance of miRNA dysregulation in cancer.
Journal ArticleDOI
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches
TL;DR: This review guides the reader through important aspects of non-coding RNA biology, including their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system).
Journal ArticleDOI
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
TL;DR: The roles of miRNAs and lncRNAs in cancer are summarized, with a focus on the recently identified novel mechanisms of action, and the current strategies in designing ncRNA-targeting therapeutics are discussed.
References
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Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA signatures in human cancers
George A. Calin,Carlo M. Croce +1 more
TL;DR: MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
Journal Article
MicroRNA signatures in human cancers
George A. Calin,Carlo M. Croce +1 more
TL;DR: The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery as discussed by the authors.
Journal ArticleDOI
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
George A. Calin,Calin Dan Dumitru,Masayoshi Shimizu,Roberta Bichi,Simona Zupo,Evan Noch,Hansjuerg Aldler,Sashi Rattan,Michael J. Keating,Kanti R. Rai,Laura Z. Rassenti,Thomas J. Kipps,Massimo Negrini,Florencia Bullrich,Carlo M. Croce +14 more
TL;DR: Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (≈68%) of CLL cases.
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