Journal ArticleDOI
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment
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TLDR
The current knowledge of miRNAs is summarized, their roles in lung cancer and avenues for future research are summarized, and a call for further research into these regulators is made.Abstract:
MicroRNAs (miRNAs) are short non-protein-coding RNAs that post-transcriptionally regulate mRNA expression. A large body of evidence has identified important roles for these regulators in cell proliferation, differentiation, apoptosis and metabolism, as well as activation of oncogenic and antioncogenic signals. Aberrant expression of miRNAs has been found in most human malignancies and is strongly associated with tumorigenesis, prediction, diagnosis, progress, treatment and prognosis. Thus, miRNAs may become an intriguing and promising therapeutic target for many diseases, including cancer. In addition, research into miRNAs may provide insight into the mechanisms underlying tumor occurrence, progression and metastasis. This review summarizes the current knowledge of miRNAs, their roles in lung cancer and avenues for future research.read more
Citations
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MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1
TL;DR: The findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression.
Journal ArticleDOI
Lung cancer biomarkers: State of the art
Sangeetha Subramaniam,Ram Krishna Thakur,Vinod Kumar Yadav,Ranjan Kumar Nanda,Shantanu Chowdhury,Anurag Agrawal +5 more
TL;DR: This mini review is intended to provide an overview of the field, briefly discussing the potential of what is known and highlighting the exciting recent developments, particularly with miRNAs and VOCs.
Screening for Lung Cancer: Systematic Review to Update the U.S. Preventive Services Task Force Recommendation
Linda Humphrey,Mark Deffebach,Miranda Pappas,Christina Baumann,Katie Artis,Jennifer Priest Mitchell,Bernadette Zakher,Rongwei Fu,Christopher G. Slatore +8 more
TL;DR: Low-dose computed tomography (LDCT) and chest X-ray (CXR) have been studied for early screening, with several new studies reporting results since the last review.
Journal ArticleDOI
MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC.
Wei Chen,Jun Wang,Sulai Liu,Shaoqiang Wang,Yuanda Cheng,Wolong Zhou,Chaojun Duan,Chunfang Zhang +7 more
TL;DR: miR-361-3p functions as a novel tumor suppressor in NSCLC and the anti-oncogenic activity may involve its inhibition of the target gene SH2B1.
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