Microtubule dynamics in axon guidance
Guofa Liu,Trisha Dwyer +1 more
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TLDR
Understanding the functions and regulation of microtubule dynamics in the growth cone provides new insights into the molecular mechanisms of axon guidance.Abstract:
Precise modulation of the cytoskeleton is involved in a variety of cellular processes including cell division, migration, polarity, and adhesion. In developing post-mitotic neurons, extracellular guidance cues not only trigger signaling cascades that act at a distance to indirectly regulate microtubule distribution, and assembly and disassembly in the growth cone, but also directly modulate microtubule stability and dynamics through coupling of guidance receptors with microtubules to control growth-cone turning. Microtubule-associated proteins including classical microtubule-associated proteins and microtubule plus-end tracking proteins are required for modulating microtubule dynamics to influence growth-cone steering. Multiple key signaling components, such as calcium, small GTPases, glycogen synthase kinase-3β, and c-Jun N-terminal kinase, link upstream signal cascades to microtubule stability and dynamics in the growth cone to control axon outgrowth and projection. Understanding the functions and regulation of microtubule dynamics in the growth cone provides new insights into the molecular mechanisms of axon guidance.read more
Citations
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Journal ArticleDOI
The axonal cytoskeleton: from organization to function
TL;DR: An overview of the current understanding of actin and microtubule organization within the axon is provided and models for the functional role of the cytoskeleton at specialized axonal structures are discussed.
Journal ArticleDOI
Neurodegeneration and microtubule dynamics: death by a thousand cuts.
TL;DR: The ratio of stable and dynamic microtubules is likely to be important for neuronal function and perturbation in microtubule dynamics might contribute to disease progression.
Journal ArticleDOI
Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport
Maria M. Magiera,Maria M. Magiera,Satish Bodakuntla,Satish Bodakuntla,Jakub Žiak,Jakub Žiak,Sabrina Lacomme,Patricia Marques Sousa,Patricia Marques Sousa,Sophie Leboucher,Sophie Leboucher,Torben J. Hausrat,Christophe Bosc,Christophe Bosc,Annie Andrieux,Annie Andrieux,Matthias Kneussel,Marc Landry,André Calas,Martin Balastik,Carsten Janke,Carsten Janke +21 more
TL;DR: It is demonstrated that excessive polyglutamylation induces neurodegeneration in a cell‐autonomous manner and can occur in many parts of the central nervous system, suggesting that impaired cargo transport plays an important role in the observed degenerative phenotypes.
Journal ArticleDOI
Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes
TL;DR: Findings indicate the cooperative functions of tau and MAP1B in vivo in axonal elongation and neuronal migration as regulators of microtu-
Journal ArticleDOI
Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration
Vandana Shashi,Maria M. Magiera,Maria M. Magiera,Dennis Klein,Maha S. Zaki,Kelly Schoch,Sabine Rudnik-Schöneborn,A. Norman,Osorio Abath Neto,Marina Dusl,Xidi Yuan,Luca Bartesaghi,Patrizia De Marco,Ahmed Alfares,Ronit Marom,Ronit Marom,Stefan T. Arold,Francisco J. Guzmán-Vega,Loren D M Pena,Loren D M Pena,Edward C. Smith,Maja Steinlin,Mohamed Oe Babiker,Payam Mohassel,A. Reghan Foley,Sandra Donkervoort,Rupleen Kaur,Partha S. Ghosh,Valentina Stanley,Damir Musaev,Caroline Nava,Cyril Mignot,Boris Keren,Marcello Scala,Elisa Tassano,Paolo Picco,Paola Doneda,Chiara Fiorillo,Chiara Fiorillo,Mahmoud Y. Issa,Ali H. Alassiri,Ahmed Alahmad,Amanda Gerard,Amanda Gerard,Pengfei Liu,Pengfei Liu,Yaping Yang,Yaping Yang,Birgit Ertl-Wagner,Peter G. Kranz,Ingrid M. Wentzensen,Rolf Stucka,Nicholas Stong,Andrew S. Allen,David Goldstein,Benedikt Schoser,Kai Michael Rösler,Majid Alfadhel,Valeria Capra,Roman Chrast,Tim M Strom,Erik-Jan Kamsteeg,Carsten G. Bönnemann,Joseph G. Gleeson,Rudolf Martini,Carsten Janke,Jan Senderek,Jan Senderek +67 more
TL;DR: This work found biallelic rare and damaging variants in the gene encoding CCP1 in 13 individuals with infantile‐onset neurodegeneration and confirmed the absence of functional CCP1 along with dysregulated tubulin polyglutamylation, entailing this post‐translational modification as a potential target for drug development for neuro degenerative disorders.
References
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Journal ArticleDOI
Beyond self-assembly: from microtubules to morphogenesis
Journal ArticleDOI
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
Tito Serafini,Sophia A. Colamarino,E.David Leonardo,Hao Wang,Rosa S. P. Beddington,William C. Skarnes,Marc Tessier-Lavigne +6 more
TL;DR: Results establish netrin-1 as a guidance cue that likely collaborates with other diffusible cues to guide axons in vivo and evidence is provided for a distinct trochlear axon chemorepellent produced by floor plate cells.
Journal ArticleDOI
Microtubule assembly, organization and dynamics in axons and dendrites.
Cecilia Conde,Alfredo Cáceres +1 more
TL;DR: Current understanding of the regulation of microtubule assembly, organization and dynamics in axons and dendrites is reviewed to provide new insight into microtubules' function in neuronal development and their potential contribution to plasticity.
Journal ArticleDOI
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease
TL;DR: Recent studies have begun to clarify the mechanisms of cargo selection and directional transport in subcellular compartments and molecular genetics has revealed unexpected roles for molecular motors in brain wiring, neuronal survival, neuronal plasticity, higher brain function, and control of central nervous system and peripheral nervous system development.
Journal ArticleDOI
The many faces of tau.
TL;DR: While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged and their potential roles in neurodegenerative disease are highlighted.
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