Microwave-Assisted Synthesis of Six-Membered O-Heterocycles
TL;DR: An overview of the application of microwave irradiation in oxygen-containing six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5-10 years as mentioned in this paper.
About: This article is published in Synthetic Communications.The article was published on 2014-09-10. It has received 47 citations till now. The article focuses on the topics: Total synthesis.
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TL;DR: In many cases, these processes provide access to unique modes of reactivity or offer unriva... as discussed by the authors, and they have been applied for the synthesis of complex targets in many examples recently.
39 citations
TL;DR: In this paper, the use of ionic liquid salts as solvents and catalal acid as catal acid is investigated for the replacement of organic solvers in chemical synthesis due to increasing environmental issues.
35 citations
TL;DR: In this paper, the synthesis of six-membered N-heterocylces in the presence of ruthenium catalyst was studied and a new protocol was proposed for the synthesis.
Abstract: A wide variety of biological activities are possessed by nitrogen, oxygen, and sulfur containing heterocycles and many methods are explored for the preparation of these heterocyclic compounds. Metal catalysts worked with high activity in organic reactions. The synthesis of heterocycles with the help of metal catalysts became very important in organic synthesis. New protocols have been investigated for the synthesis of heterocycles in the last decades. This article mainly focused on the synthesis of six-membered N-heterocylces in the presence of ruthenium catalyst.
33 citations
TL;DR: In this article, metal and non-metal catalysts are used in organic reactions with high activity, such as Nitrogen, oxygen, and sulfur containing heterocycles have a wide range of biological activities.
Abstract: Nitrogen, oxygen, and sulfur containing heterocycles have a wide range of biological activities. Metal and nonmetal catalysts are used in organic reactions with high activity. New strategie...
32 citations
TL;DR: In this article, the authors proposed a new strategy for the synthesis of new strategies for synthesizing new drugs and pesticides using heterocycles, which is an interesting topic for the synthetic and m...
30 citations
References
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TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
Abstract: Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds. With a small set of starting materials, very large libraries can be built up within a short time, which can then be used for research on medicinal substances. Due to the intensive research of the last few years, many new backbone types have become accessible. MCRs are also increasingly being employed in the total synthesis of natural products. MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures. However, this requires that the chemist learns the “language” of MCRs, something that this review wishes to stimulate.
3,619 citations
TL;DR: The results show clear trends in gold-Catalyzed C-H Bond Functionalization and Selective Reductions, and catalytic Hydrogenation of Alkenes and 1,3-Dienes, as well as in other areas of science.
Abstract: 2.7. Hydroxylation Reactions of Allenes 3282 2.8. Hydroamination Reactions of Allenes 3284 2.9. Hydrothiolation of Allenes 3284 2.10. Hydroalxoxylation of Alkenes and 1,3-Dienes 3286 2.11. Hydroamination of Alkenes and 1,3-Dienes 3287 2.12. Hydrothiolation of Conjugated Olefins 3289 3. Activation of Carbonyl/Imine Groups and Alcohols 3289 3.1. Condensation Reactions 3289 3.2. Addition Reactions 3291 3.3. Aldol Reactions 3294 3.4. Hydroand Carbosilylation Reactions 3295 3.5. Nucleophilic Substitution Reactions of Alcohols 3297 4. Gold-Catalyzed C-H Bond Functionalization 3297 4.1. Csp3-H Bond Functionalization 3298 4.2. Csp2-H Bond Functionalization 3299 4.3. Csp-H Bond Functionalization 3304 5. Gold-Catalyzed Selective Reductions 3305 5.1. Catalytic Hydrogenation of Alkenes 3306 5.2. Selective Reductions of R, -Unsaturated Carbonyl Groups and 1,3-Dienes 3306
1,358 citations
TL;DR: In this paper, microwave-accelerated solventless organic syntheses are summarised and the salient features of these high yield protocols are the enhanced reaction rates, greater selectivity and the experimental ease of manipulation.
1,190 citations
1,143 citations
TL;DR: The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance and encompass the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles.
Abstract: This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.
752 citations