Mid-regional pro-adrenomedullin as a supplementary tool to clinical parameters in cases of suspicion of infection in the emergency department.
Kordo Saeed,Jacopo M. Legramante,Silvia Angeletti,Francesco Curcio,Iria Miguens,Stephen Poole,Carlo Tascini,Emanuela Sozio,Juan González del Castillo +8 more
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In this paper, the authors provide evidence related to MR-proADM as a triaging tool in avoiding unnecessary admissions to hospital and/or inadequate discharge, and identifying patients most at risk of deterioration.Abstract:
INTRODUCTION: Mid-regional proadrenomedullin (MR-proADM), a novel biomarker, has recently gained interest particularly with regards to its potential in assisting clinicians' decision making in patients with suspicion of infection in the emergency department (ED). A group of international experts, with research and experience in MR-proADM applications, produced this review based on their own experience and the currently available literature. AREAS COVERED: The review provides evidence related to MR-proADM as a triaging tool in avoiding unnecessary admissions to hospital and/or inadequate discharge, and identifying patients most at risk of deterioration. It also covers the use of MR-proADM in the context of COVID-19. Moreover, the authors provide a proposal on how to incorporate MR-proADM into patients' clinical pathways in an ED setting. EXPERT OPINION: The data we have so far on the application of MR-proADM in the ED is promising. Incorporating it into clinical scoring systems may aid the clinician's decision making and recognizing the 'ill looking well' and the 'well looking ill' sooner. However there are still many gaps in our knowledge especially during the ongoing COVID-19 waves. There is also a need for cost-effectiveness analysis studies especially in the era of increasing cost pressures on health systems globally.read more
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Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients.
Luis García de Guadiana-Romualdo,Monica Martinez,María Dolores Rodríguez Mulero,Patricia Esteban-Torrella,Marta Hernández Olivo,María José Alcaraz García,Valerio Campos-Rodríguez,Natalia Sancho-Rodríguez,María Galindo Martínez,Antonia Alcaraz,María Salomé Ros Braquehais,Carlos Báguena Perez-Crespo,Verónica Ramos Arenas,Cristina Tomás Jiménez,Luciano Consuegra-Sánchez,Andrés Conesa-Hernandez,Pascual Piñera-Salmerón,Enrique Bernal-Morell +17 more
TL;DR: In this article, the role of MR-proADM in the mid-term mortality in COVID-19 patients was evaluated and it was shown that MR-ProADM levels (inverse transformed), after adjusting by a propensity score including eleven potential confounders, were an independent predictor of 90-day mortality.
Journal ArticleDOI
Plasma Levels of Mid-Regional Proadrenomedullin Accurately Identify H1N1pdm09 Influenza Virus Patients with Risk of Intensive Care Admission and Mortality in the Emergency Department
Blanca Valenzuela-Méndez,Francisco Valenzuela-Sánchez,J. F. Rodríguez-Gutiérrez,Rafael Bohollo-de-Austria,Angel Estella,P. Martínez García,María Ángela González-García,Jordi Rello +7 more
TL;DR: The initial MR-proadrenomedullin, ferritin, CRP, and PCT levels effectively determine adverse outcomes and risk of ICU admission and mortality in patients with influenza virus pneumonia.
Journal ArticleDOI
Proadrenomedullin in the Management of COVID-19 Critically Ill Patients in Intensive Care Unit: A Systematic Review and Meta-Analysis of Evidence and Uncertainties in Existing Literature
Giorgia Montrucchio,Eleonora Balzani,Davide Lombardo,Alice Giaccone,Anna Vaninetti,Giulia D'Antonio,Francesca Rumbolo,Giulio Mengozzi,Luca Brazzi +8 more
TL;DR: MR-proADM ICU admission levels seem to predict mortality among the critical COVID-19 population, and prospective studies, focused on critically ill patients and investigating a reliable MR-proadrenomedullin cut-off, are needed to provide adequate guidance to its use in severe CO VID-19.
Journal ArticleDOI
Implications of Using Host Response-Based Molecular Diagnostics on the Management of Bacterial and Viral Infections: A Review
TL;DR: This review will highlight recent publications on the current use of host-based diagnostics alone or in combination with traditional microbiological assays and their potential future implications on the diagnosis and prognostic accuracy for the patient with infectious complications.
Journal ArticleDOI
Mid-Regional Pro-Adrenomedullin in Combination With Pediatric Early Warning Scores for Risk Stratification of Febrile Children Presenting to the Emergency Department: Secondary Analysis of a Nonprespecified United Kingdom Cohort Study*
TL;DR: In this paper , the utility of mid-regional pro-adrenomedullin (MR-proADM) in identification of patient subgroups at risk of requiring PICU or high-dependency unit (HDU) admission or fluid resuscitation was evaluated.
References
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