MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
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...Notably, neutralizing the noncanonical chemokine macrophage migration inhibitory factor (MIF) caused regression of established lesions, probably because of its CXCR2 and CXCR4 agonist effect, which promoted macrophage and T-cell infiltratio...
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1,475 citations
Cites background from "MIF is a noncognate ligand of CXC c..."
...and macrophages, leading to CXCR2 signaling and integrin-dependent chemotaxis of monocytes, which is necessary for the maintenance of atherosclerotic plaques (105)....
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1,344 citations
Cites background from "MIF is a noncognate ligand of CXC c..."
...Binding of MIF to its newly discovered receptor complex of CXCR2 and CD74 resulted in elevated monocyte arrest on atherosclerotic endothelium (130)....
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1,234 citations
Cites methods from "MIF is a noncognate ligand of CXC c..."
...The extent of atherosclerosis was assessed in aortic roots by detecting lipid deposition with Oil Red O (29, 40, 41) in 5-mm transversal sections....
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References
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"MIF is a noncognate ligand of CXC c..." refers background in this paper
...An impressive body of evidence supports the concept that atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by an influx of immunocompetent mononuclear cell...
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"MIF is a noncognate ligand of CXC c..." refers background in this paper
...JAM-1 is a ligand of the b(2) integrin LFA-1 involved in transendothelial migration of leukocytes....
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2,281 citations