Abstract: Preface. Part I: Theory. Some History Leading to Design Criteria for Bayesian Prediction A.C. Atkinson, V.V. Fedorov. Optimal Designs for the Evaluation of an Extremum Point R.C.H. Cheng, et al. On Regression Experiment Design in the Presence of Systematic Error S.M. Ermakov. Groebner Basis Methods in Mixture Experiments and Generalisations B. Giglio, et al. Efficient Designs for Paired Comparisons with a Polynomial Factor H. Grossmann, et al. On Generating and Classifying All qn-m Regular Designs for Square-Free q P.J. Laycock, P.J. Rowley. Second-Order Optimal Sequential Tests M.B. Malyutov, I.I. Tsitovich. Variational Calculus in the Space of Measures and Optimal Design I. Molchanov, S. Zuyev. On the Efficiency of Generally Balanced Designs Analysed by Restricted Maximum Likelihood H. Monod. Concentration Sets, Elfving Sets and Norms in Optimum Design A. Pazman. Sequential Construction of an Experimental Design from an I.I.D. Sequence of Experiments without Replacement L. Pronzato. Optimal Characteristic Designs for Polynomial Models J.M. Rodriguez-Diaz, J. Lopez-Fidalgo. A Note on Optimal Bounded Designs M. Sahm, R. Schwabe. Construction of Constrained Optimal Designs B. Torsney, S. Mandal. Part II: Applications. Pharmaceutical Applications of a Multi-Stage Group Testing Method B. Bond, et al. Block Designs for Comparison of Two Test Treatments with a Control S.M. Bortnick, et al. Optimal Sampling Design with Random Size Clusters for a Mixed Model with Measurement Errors A. Giovagnoli, L. Martino. Optimizing a Unimodal Response Function for Binary Variables J. Hardwick, Q.F. Stout. An Optimizing Up-And-Down Design E.E. Kpamegan, N.Flournoy. Further Results on Optimal and Efficient Designs for Constrained Mixture Experiments R.J. Martin, et al. Coffee-House Designs W.G. Muller. (D,t, C)-Optimal Run Orders L. Tack, M. Vandebroek. Optimal Design in Flexible Models, including Feed-Forward Networks and Nonparametric Regression D.M. Titterington. On Optimal Designs for High Dimensional Binary Regression Models B. Torsney, N. Gunduz. Planning Herbicide Dose-Response Bioassays Using the Bootstrap S.S. Zocchi, C.G. Borges Demetrio. Photo Gallery. Optimum Design 2000: List of Participants.