MiR-101 induces senescence and prevents apoptosis in the background of DNA damage in MCF7 cells.
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Cites background or result from "MiR-101 induces senescence and prev..."
...confirmed by us in an earlier report on the involve ment of miR-101 in senescence [23]....
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...Ectopic expression of miR101 has also been shown to enhance the sensitivity of cancer cells to radiation, cisplatin a d etoposide [23; 32; 33; 34]....
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...results in inhibiting proliferation either by induc ing apoptosis or senescence [23; 24; 25; 26; 27]....
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27 citations
27 citations
Cites background from "MiR-101 induces senescence and prev..."
...miR-101 may also induce senescence in breast cancer cells by targeting ubiquitinconjugating enzyme E2N (UBE2N)- and SWI/SNF-related, matrixassociated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4 )([57]) and inhibit the G1-to-S phase transition of cervical cancer cells by targeting FBJ murine osteosarcoma viral oncogene homolog (Fos)([58])....
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...Thus, miR-101 may act as a suppressor of tumor progression. miR-101 may suppress tumor proliferation and migration and induce apoptosis by targeting enhancer of zeste homolog 2 (EZH2)[54,55] and Janus kinase 2 (JAK2)[56]. miR-101 may also induce senescence in breast cancer cells by targeting ubiquitinconjugating enzyme E2N (UBE2N)- and SWI/SNF-related, matrixassociated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4 )[57] and inhibit the G1-to-S phase transition of cervical cancer cells by targeting FBJ murine osteosarcoma viral oncogene homolog (Fos)[58]....
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...Chin J Cancer; 2015; Vol. 34 Issue 1 Chinese Journal of Cancer Like most miRNAs, miR-101 acts as a tumor suppressor in cancers by targeting the 3-UTR of multiple genes, including EZH2[54], UBE2N and SMARCA4 [57], mitogen-activated protein kinase 1 (MAPK1) and Fos[59], Kruppel-like factor 6 (KLF6)[60], DNA (cytosine5-)-methyltransferase 3 alpha (DNMT3A)[61], and cyclooxygenase-2 (COX-2)[62]....
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...34 Issue 1 Chinese Journal of Cancer Like most miRNAs, miR-101 acts as a tumor suppressor in cancers by targeting the 3-UTR of multiple genes, including EZH2([54]), UBE2N and SMARCA4 ([57]), mitogen-activated protein kinase 1 (MAPK1) and Fos([59]), Kruppel-like factor 6 (KLF6)([60]), DNA (cytosine5-)-methyltransferase 3 alpha (DNMT3A)([61]), and cyclooxygenase-2 (COX-2)([62])....
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16 citations
Cites background from "MiR-101 induces senescence and prev..."
...In addition, the effect of such a treatment on senescent cells, over-expressing hsamiR-101 (Manvati et al., 2014), was also expedited....
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..., 2007) and hsa-miR-24-2 in combination and also to understand the effect of such a treatment on senescent cells, overexpressing hsa-miR-101, an inducer of senescence (Manvati et al., 2014)....
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References
10 citations
"MiR-101 induces senescence and prev..." refers background in this paper
...Both miR-101 for exogenous (after transfection) and etoposide, one of the widely studied agents [25,26], for endogenous induction of DNA Damage (as assessed in the present work), were used for experimentation....
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9 citations
7 citations
"MiR-101 induces senescence and prev..." refers background in this paper
...The extent of apoptosis was quantified as the percentage of annexin V-positive cells [29]....
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