Journal ArticleDOI
miR-214 targets ATF4 to inhibit bone formation
Xiaogang Wang,Baosheng Guo,Baosheng Guo,Qi Li,Jiang Peng,Zhijun Yang,Aiyuan Wang,Dong Li,Zhibo Hou,Ke Lv,Guanghan Kan,Hongqing Cao,Heng Wu,Heng Wu,Jinping Song,Xiaohua Pan,Qiao Sun,Shukuan Ling,Yuheng Li,Mu Zhu,Pengfei Zhang,Songlin Peng,Xiaoqing Xie,Tao Tang,An Hong,Zhaoxiang Bian,Yanqiang Bai,Aiping Lu,Yinghui Li,Fuchu He,Ge Zhang,Ge Zhang,Yingxian Li +32 more
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TLDR
Elevated miR-214 levels correlated with a lower degree of bone formation in bone specimens from aged patients with fractures, and in vitro osteoblast activity and matrix mineralization were promoted by antagomir-214 and decreased by agomIR-214, and mi R-214 directly targeted ATF4 to inhibit osteoblasts activity.Abstract:
In a new study Yingxian Li and her colleagues show that the microRNA miR-214 targets ATF4 in osteoblasts to negatively regulate their activity. Manipulating miR-214 levels experimentally showed that its elevated expression is sufficient to induce bone loss in mice and that its therapeutic inhibition reduces bone loss in two mouse models.read more
Citations
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Journal ArticleDOI
Osteoblast–osteoclast interactions
TL;DR: The current knowledge on osteoblast–osteoclast communication is summarized and drugs could be developed by enhancing or restricting some of these interactions.
Journal ArticleDOI
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Defang Li,Jin Liu,Baosheng Guo,Chao Liang,Lei Dang,Cheng Lu,Cheng Lu,Xiaojuan He,Xiaojuan He,Hilda Y. S. Cheung,Liang Xu,Changwei Lu,Bing He,Biao Liu,Atik Badshah Shaikh,Fangfei Li,Luyao Wang,Zhijun Yang,Doris W.T. Au,Songlin Peng,Zong-Kang Zhang,Bao-Ting Zhang,Xiaohua Pan,Xiaohua Pan,Airong Qian,Airong Qian,Peng Shang,Peng Shang,Lianbo Xiao,Lianbo Xiao,Baohong Jiang,Chris K C Wong,Jiake Xu,Zhaoxiang Bian,Zicai Liang,De-An Guo,Hailong Zhu,Weihong Tan,Aiping Lu,Ge Zhang +39 more
TL;DR: The results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation, which may be a strategy for treating skeletal disorders involving a reduction in bone formation.
Journal ArticleDOI
Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration.
TL;DR: This review provides a concise report of the regulation of angiogenesis by bone cells, its importance during bone healing and its possible therapeutic applications in bone tissue engineering.
Journal ArticleDOI
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.
TL;DR: The regulatory mechanisms underlying UPR signaling upon cell intrinsic or extrinsic challenges are described, and how they engage cell transformation programs and/or provide advantages to cancer cells, leading to enhanced aggressiveness or chemoresistance.
Journal ArticleDOI
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy.
Chao Liang,Baosheng Guo,Heng Wu,Ningsheng Shao,Defang Li,Jin Liu,Lei Dang,Cheng Wang,Hui Li,Shaohua Li,Wing Ki Lau,Yu Cao,Zhijun Yang,Cheng Lu,Xiaojuan He,Doris W.T. Au,Xiaohua Pan,Bao-Ting Zhang,Changwei Lu,Hong Qi Zhang,Kinman Yue,Airong Qian,Peng Shang,Jiake Xu,Lianbo Xiao,Zhaoxiang Bian,Weihong Tan,Zicai Liang,Fuchu He,Lingqiang Zhang,Aiping Lu,Ge Zhang +31 more
TL;DR: The results indicate that osteoblast-specific aptamer-functionalized LNPs could act as a new RNAi-based bone anabolic strategy, advancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular level.
References
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The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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Osteoclast differentiation and activation
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TL;DR: A better understanding of the biology of osteoclasts and osteoblasts is providing opportunities for developing therapeutics to treat diseases of bone, and promoting bone formation with growth factors or hormones is an approach that would be a valuable adjunct therapy for patients receiving inhibitors of bone resorption.
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TL;DR: The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength.
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MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN.
Hua Yang,William Kong,Lili He,Jian-jun Zhao,Joshua D. O'Donnell,Jia-Wang Wang,Robert M. Wenham,Domenico Coppola,Patricia A. Kruk,Santo V. Nicosia,Jin Q. Cheng +10 more
TL;DR: It is indicated that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway.
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Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Defang Li,Jin Liu,Baosheng Guo,Chao Liang,Lei Dang,Cheng Lu,Cheng Lu,Xiaojuan He,Xiaojuan He,Hilda Y. S. Cheung,Liang Xu,Changwei Lu,Bing He,Biao Liu,Atik Badshah Shaikh,Fangfei Li,Luyao Wang,Zhijun Yang,Doris W.T. Au,Songlin Peng,Zong-Kang Zhang,Bao-Ting Zhang,Xiaohua Pan,Xiaohua Pan,Airong Qian,Airong Qian,Peng Shang,Peng Shang,Lianbo Xiao,Lianbo Xiao,Baohong Jiang,Chris K C Wong,Jiake Xu,Zhaoxiang Bian,Zicai Liang,De-An Guo,Hailong Zhu,Weihong Tan,Aiping Lu,Ge Zhang +39 more