Journal ArticleDOI
MiR-26a-5p alleviates cardiac hypertrophy and dysfunction via targeting ADAM17.
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TLDR
Wang et al. as discussed by the authors used thoracic aortic constriction (TAC)-induced mice and Angiotensin-II (Ang-II)-induced H9C2 cell line as cardiac hypertrophy model to investigate the role of miR-26a-5p in cardiac hyperphy.About:
This article is published in Cell Biology International.The article was published on 2021-08-09. It has received 10 citations till now. The article focuses on the topics: Muscle hypertrophy.read more
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The miR-26a-5p/IL-6 axis alleviates sepsis-induced acute kidney injury by inhibiting renal inflammation
TL;DR: In this paper , the miR-26a-5p/IL-6 axis was shown to alleviate sepsis-induced acute kidney injury by inhibiting renal inflammation, which is a common and life-threatening complication in hospitalized and critically ill patients and has unacceptable morbidity and mortality rates.
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Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression
Yoke Chin Chai,Sajal Nag +1 more
TL;DR: In this paper , the authors generated cardiac organoids from patient-derived induced pluripotent stem cells (DMD-COs) and isogenic-corrected controls and studied if DMD-related cardiomyopathy and disease progression occur in the organoids upon long-term culture (up to 93 days).
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Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression
Vittoria Marini,Fabiola Marino,Flaminia Aliberti,Nefele Giarratana,Enrico Pozzo,Robin Duelen,Alvaro Cortes Calabuig,Rita Larovere,Tim Vervliet,Daniele Torella,Geert Bultynck,Maurilio Sampaolesi,Yoke Chin Chai +12 more
TL;DR: A patient-derived cardiac organoid model is generated that displayed DMD-related cardiomyopathy and disease progression phenotypes in long-term culture and envision the feasibility to develop a more complex, realistic and reliable in vitro 3D human cardiac-mimics to study D MD-relatedCardiomyopathies.
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Non-coding RNAs in cardiac remodeling: diversity in composition and function
Emeli Chatterjee,Saumya Das +1 more
TL;DR: In this paper , the authors provide an update on the current knowledge on the role of small ncRNAs (including microRNAs, PIWI-interacting RNAs, and tRNA-derived small RNAs), and circular RNAs in cardiac remodeling.
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MicroRNA-194 inhibits isoproterenol-induced chronic cardiac hypertrophy via targeting CnA/NFATc2 signaling in H9c2 cells
TL;DR: Increasing the expression of miR-194 can alleviate chronic cardiac hypertrophy by targeting can and inhibiting the CnA/NFATc2 pathway.
References
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MicroRNAs in cancer.
TL;DR: In this paper, the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies are discussed.
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The ADAMs family of metalloproteases: multidomain proteins with multiple functions
TL;DR: This review will first discuss the properties of each of the domains of the ADAMs, then describe the involvement ofADAMs in selected biological processes, and highlight recent interesting findings suggesting roles for ADams in human disease.
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The microcosmos of cancer
TL;DR: The discovery of microRNAs almost two decades ago established a new paradigm of gene regulation, and during the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer.
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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
Umut Sahin,Gisela Weskamp,Kristine Kelly,Kristine Kelly,Hong-Ming Zhou,Shigeki Higashiyama,Jacques J. Peschon,Dieter Hartmann,Paul Saftig,Carl P. Blobel +9 more
TL;DR: This comprehensive evaluation of EG FR ligand shedding in a defined experimental system demonstrates that ADAMs have critical roles in releasing all EGFR ligands tested here, and has implications for designing novel inhibitors of EGFR-dependent tumors.
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Mechanisms of physiological and pathological cardiac hypertrophy
TL;DR: The characteristics and underlying mechanisms of physiological and pathological hypertrophy are summarized, and possible therapeutic strategies targeting these pathways to prevent or reverse pathological hyperTrophy are discussed.