miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
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Cites background from "miR-9, a MYC/MYCN-activated microRN..."
...They act as sponges for cognate miRNAs, preventing their association with natural target...
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Cites background from "miR-9, a MYC/MYCN-activated microRN..."
...Cancer cells are not just characterized by the propensity to proliferate with disregard to extracellular cues but also underscored by increased genomic instability, changes in morphology and function such as epithelial-mesenchymal transition (EMT), and an increased ability to metastasize....
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...Myc has been linked to EMT and metastasis via its regulation of miRNA miR-9, which targets E-cadherin, as well as its ability to transactivate Bmi-1 which is linked to EMT (Ma et al., 2010; Song et al., 2009)....
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...The miR-17 cluster contains miRNAs that target PTEN, thereby activating AKT, and those that target proapoptotic BimL or transcription factor E2F1 expression. miRNAs downstream of Myc have also been implicated in EMT and angiogenesis....
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2,136 citations
References
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"miR-9, a MYC/MYCN-activated microRN..." refers methods in this paper
...In a preliminary survey we used several computational algorithms, including TargetSca...
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8,052 citations
"miR-9, a MYC/MYCN-activated microRN..." refers background in this paper
...Alternatively, the apparent ability of miR-9 to induce an EMT in HMLE cells might be explained by selection for a pre-existing rare mesenchymal subpopulation present within this particular cell lin...
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6,362 citations
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