Journal ArticleDOI
Mismatch repair status in sporadic colorectal cancer: immunohistochemistry and microsatellite instability analyses.
Yong Sik Yoon,Chang Sik Yu,Tae Won Kim,Jong Hoon Kim,Se Jin Jang,Dong-Hyung Cho,Dong-Hyung Cho,Seon Ae Roh,Jin Cheon Kim +8 more
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TLDR
Evaluated associations between mismatch repair (MMR) status and clinicopathological characteristics and prognosis using immunohistochemistry (IHC) and microsatellite instability (MSI) analyses in a prospective cohort of a large number of accumulated samples.Abstract:
Background and Aim: The aim of the present study was to evaluate associations between mismatch repair (MMR) status and clinicopathological characteristics and prognosis using immunohistochemistry (IHC) and microsatellite instability (MSI) analyses in a prospective cohort of a large number of accumulated samples.
Methods: Tumor tissue samples obtained during curative surgery (n = 2028) were analyzed using both MLH1/MSH2 IHC and MSI assays. Clinicopathological parameters and survival outcomes were compared according to IHC and MSI results. The median follow-up period was 43 months (range: 1–85 months).
Results: IHC identified 207 tumor samples (10.2%) with a loss of either MLH1 or MSH2 expression. The MSI analysis identified 203 tumor samples (10%) with high-frequency MSI (MSI-H). Patients with MMR defects were younger, and had tumors characterized by right-colon predilection; large-size, infrequent lymph node metastasis; poorly-differentiated or mucinous histology, and synchronous adenomas (P < 0.001–0.008). Patients with MSI-H status had higher 4-year disease-free survival rates than patients with microsatellite stable status (90.8% vs 80.6%, P = 0.001). A multivariate analysis showed that MSI-H status was a good prognostic factor for recurrence (hazard ratio: 0.48, 95% confidence interval: 0.30–0.83, P = 0.007).
Conclusions: Patients with MMR defects had distinct clinicopathological characteristics, including a lower risk of recurrence. IHC and MSI analyses provided complementary information regarding specific clinicopathological parameters and prognosis.read more
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Journal ArticleDOI
Poorly Differentiated Colorectal Cancers
Haitao Xiao,Haitao Xiao,Yong Sik Yoon,Yong Sik Yoon,Seung-Mo Hong,Seon Ae Roh,Seon Ae Roh,Dong-Hyung Cho,Dong-Hyung Cho,Chang Sik Yu,Jin Cheon Kim,Jin Cheon Kim +11 more
TL;DR: The clinicopathologic characteristics of PD were closely associated with those of microsatellite instability, and the outcomes of MSI-PD tumors were better than those of MSS- PD tumors, but this finding did not reach statistical significance.
Journal ArticleDOI
RSPO fusion transcripts in colorectal cancer in Japanese population
Kazuya Shinmura,Tomoaki Kahyo,Hisami Kato,Hisaki Igarashi,Shun Matsuura,Satoki Nakamura,Kiyotaka Kurachi,Toshio Nakamura,Hiroshi Ogawa,Kazuhito Funai,Masayuki Tanahashi,Hiroshi Niwa,Haruhiko Sugimura +12 more
TL;DR: The forced expression of RSPO fusion proteins were shown to endow colorectal cells with an increased growth ability and suggest that the expression of r-spondin fusion transcripts is related to a subset of CRCs arising in the Japanese population.
Journal ArticleDOI
Prognostic implication of mucinous histology in colorectal cancer patients treated with adjuvant FOLFOX chemotherapy
Dae Won Lee,S.-W. Han,S.-W. Han,Hyuk Joon Lee,Ye-Young Rhee,Jeong Mo Bae,Nam-Yun Cho,Kyung-Hwa Lee,Tae-You Kim,D-Y. Oh,D-Y. Oh,S.-A. Im,S.-A. Im,Yung-Jue Bang,Yung-Jue Bang,Seung-Yong Jeong,Kyu Joo Park,Jae-Gahb Park,Gyeong Hoon Kang +18 more
TL;DR: Mucinous adenocarcinoma has an adverse prognostic impact on stage II or III colorectal cancer treated with adjuvant FOLFOX and has distinct clinicopathological features compared with NMA.
Journal Article
Relationship between MLH-1, MSH-2, PMS-2,MSH-6 expression and clinicopathological features in colorectal cancer.
TL;DR: A meaningful relationship between immunohistochemical markers and clinicopathological features usually observed in tumors with microsatellite instability is found, which may arouse suspicion for MSI.
Journal ArticleDOI
miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2.
Ling Ye,Tao Jiang,Huanzhang Shao,Lin Zhong,Zhaowen Wang,Yuan Liu,Huamei Tang,Bingyu Qin,Xiaoqing Zhang,Junwei Fan +9 more
TL;DR: The study indicates that miR-1290 may become a promising biomarker of dMMR colon cancer and predicts the prognosis of stage II and III patients who receive 5-FU-based adjuvant therapy.
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Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
Christine Ribic,Daniel J. Sargent,Malcolm J. Moore,Malcolm J. Moore,Stephen N. Thibodeau,Amy J. French,Richard M. Goldberg,Stanley R. Hamilton,Stanley R. Hamilton,Pierre Laurent-Puig,Robert Gryfe,Lois E. Shepherd,Dongsheng Tu,Mark Redston,Steven Gallinger,Steven Gallinger +15 more
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Genetic instability in colorectal cancers
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