Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
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TLDR
Evidence from both sporadic and genetic forms of Parkinson's disease that implicate both mitochondria and oxidative stress as central players in disease pathogenesis are reviewed.About:
This article is published in Neurobiology of Disease.The article was published on 2013-03-01 and is currently open access. It has received 383 citations till now. The article focuses on the topics: Parkinsonism & Parkin.read more
Citations
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Journal ArticleDOI
The Role of Oxidative Stress in Neurodegenerative Diseases
TL;DR: The role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress are discussed and future directions will be outlined.
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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
Baris Bingol,Joy S. Tea,Lilian Phu,Mike Reichelt,Corey E. Bakalarski,Qinghua Song,Oded Foreman,Donald S. Kirkpatrick,Morgan Sheng +8 more
TL;DR: In this paper, Parkin ubiquitinates and tags damaged mitochondria for clearance, and USP30, a deubiquitinase localized to mitochondria, antagonizes mitophagy driven by the ubiquitin ligase parkin.
Journal ArticleDOI
Regulation of pyruvate metabolism and human disease.
TL;DR: Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.
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Deubiquitylating enzymes and drug discovery: emerging opportunities.
TL;DR: This Review discusses issues and recent advances in understanding of DUB enzymology and biology as well as technological improvements that have contributed to the current interest in DUBs as therapeutic targets in diseases ranging from oncology to neurodegeneration.
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Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.
Fabio A. Zucca,Juan Segura-Aguilar,Emanuele Ferrari,Patricia Muñoz,Irmgard Paris,David Sulzer,Tadeusz Sarna,Luigi Casella,Luigi Zecca +8 more
TL;DR: Considering the above issues, age‐related accumulation of neuromelanin in dopamine neurons shows an interesting link between aging and neurodegeneration.
References
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Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
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Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
TL;DR: A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype.
Journal ArticleDOI
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
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Hydroperoxide metabolism in mammalian organs.
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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Tohru Kitada,Shuichi Asakawa,Nobutaka Hattori,Hiroto Matsumine,Yasuhiro Yamamura,Shinsei Minoshima,Masayuki Yokochi,Yoshikuni Mizuno,Nobuyoshi Shimizu +8 more
TL;DR: Mutations in the newly identified gene appear to be responsible for the pathogenesis of Autosomal recessive juvenile parkinsonism, and the protein product is named ‘Parkin’.
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