Mitochondrial function in hypoxic ischemic injury and influence of aging.
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"Mitochondrial function in hypoxic i..." refers background in this paper
...The mitochondrial theory of aging In 1956, Harman suggested that free radicals result in cellular damage that accrues over time and causes aging (Harman, 1956)....
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"Mitochondrial function in hypoxic i..." refers background in this paper
...Mitochondrial complex III Complex III has been known for a long time to be a significant site of ROS production in the ETC (Murphy, 2009)....
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...They suggested that estradiol deficiency induced perturbations of electron transport chain (ETC) proteins may upset the stoichiometry of the ETC and contribute to increased ROS production and cardiac injury with aging....
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...The electrons pass through a series of nine FeS clusters to Coenzyme Q (CoQ) (Murphy, 2009) and eventually to the primary electron acceptor, ubiquinone....
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