Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug.
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...indicus root extract [27] and vanillin [28]....
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...tion of apoptosis, proliferation, invasion, angiogenesis and metastasis [1]....
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5,380 citations
"Mitochondrial pathway mediates the ..." refers background in this paper
...The findings support the notion that the relative concentrations of pro-apoptotic and anti-apoptotic genes may act as a rheostat for the cell death program [48]....
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3,153 citations
"Mitochondrial pathway mediates the ..." refers methods in this paper
...To better understand the mechanism of Hemidesmus, we used thapsigargin, a compound that induces the release of intracellular endoplasmic reticulum Ca stores and prevents refilling by inhibition of the endoplasmic reticulum Ca-ATPase [47]....
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...Because ADP is a potent ligand of the adenine nucleotide translocator [41], the results confirm that Hemidesmus does not stimulate the mitochondrial permeability transition through an interaction with the adenine nucleotide translocator but to an unrelated mechanism....
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