Mobilization of heavy metals by newer, therapeutically useful chelating agents
Citations
2,429 citations
791 citations
Cites background from "Mobilization of heavy metals by new..."
...Protocols determining the pharmacokinetics of DMPS and evaluating its use for diagnostic purposes have been published in Germany [101], Sweden [102, 103], New Zealand [100], and Mexico [104] and in the United States [105–109]....
[...]
536 citations
524 citations
Cites background from "Mobilization of heavy metals by new..."
...(iii) Unlike CaNa 2EDTA, succimer has specific affinity for heavy metals such as lead, arsenic, and mercury, but causes little increase in the excretion of iron, zinc, or calcium [78,81,92]....
[...]
...across the blood-brain barrier is very slow [81]....
[...]
...of encephalopathy, and cause renal toxicity [76,81,86]....
[...]
References
9,817 citations
448 citations
309 citations
"Mobilization of heavy metals by new..." refers background in this paper
...Advantages There has been extensive use of this drug in humans both in the Soviet Union and in Germany (Aposhian, 1983; Damrau, 1990; Oster and Prellwitz, 1985; Pfeifer, 1991)....
[...]
...Reviews are available (Aposhian, 1983; Hruby and Donner, 1987)....
[...]
...After administration of BAL to rabbits with arsenic intoxication, there was an increased concentration of arsenic in their brains and testes (Hoover and Aposhian, 1983; Aposhian et al., 1984)....
[...]
...For such a purpose, DMPS is more effective and useful since it can be taken orally and is less toxic than BAL (Aposhian et al., 1982; Aposhian, 1983)....
[...]
...It is my assignment to tell you about the new, orally useful chelating agents that are effective for the treatment of heavy metal or metalloid toxicity (Aposhian, 1983; Aposhian and Aposhian, 1990; Angle, 1993)....
[...]