Journal ArticleDOI
Mode of action of benzimidazoles.
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Ernest Lacey examines this example of selectivity of drug action to the ubiquitous target of these drugs, the structural protein, tubulin, and investigates why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity.About:
This article is published in Parasitology Today.The article was published on 1990-04-01. It has received 513 citations till now.read more
Citations
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Journal ArticleDOI
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
Jeffrey M. Bethony,Jeffrey M. Bethony,Simon Brooker,Marco Albonico,Stefan M. Geiger,Stefan M. Geiger,Alex Loukas,David Diemert,Peter J. Hotez +8 more
TL;DR: Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools.
Journal ArticleDOI
Human microsporidial infections.
TL;DR: Progress is being made with respect to in vitro propagation of microsporidia, which is crucial for developing antimicrosporidial drugs, and molecular techniques are being developed for diagnostic purposes, taxonomic classification, and analysis of phylogenetic relationships.
Journal ArticleDOI
Modes of Action of Anthelmintic Drugs
TL;DR: Diethylcarbamazine blocks host, and possibly parasite, enzymes involved in arachidonic acid metabolism, and enhances the innate, nonspecific immune system.
Journal ArticleDOI
Opportunities and Challenges in Antiparasitic Drug Discovery
TL;DR: Challenges and opportunities for antiparasitic drug discovery are considered, highlighting some of the progress that has been made in recent years, partly through scientific advances, but also by more effective partnership between the public and private sectors.
Book ChapterDOI
Giardia and Giardiasis
TL;DR: The intention here is to give an up-to-date overview of Giardia and giardiasis and provide an insight into the enormous wealth of literature on the subject, as well as highlight the most important recent developments and unresolved questions.
References
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Journal ArticleDOI
The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles.
Journal ArticleDOI
Interaction of oncodazole (R 17934), a new anti-tumoral drug, with rat brain tubulin
TL;DR: Binding studies by means of molecular sieving and equilibrium dialysis indicates that the drug binds to purified rat brain tubulin in a mole to mole ratio and the conclusion may be drawn that oncodazole is a true microtubule inhibitor.
Journal ArticleDOI
Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans.
L C Davidse,W Flach +1 more
TL;DR: Electrophoretic analysis of partially purified preparations of the binding protein of Aspergillus nidulans revealed the presence of proteins with similar mobilities as mammalian tubulin monomers, and it is concluded that the bindingprotein is identical with fungal tubulin.
Journal ArticleDOI
Antiparasitic drugs. iv. 2-(4'-thiazolyl)-benzimidazole, a new anthelmintic
H. D. Brown,Alexander R Matzuk,I. R. Ilves,L. H. Peterson,S. A. Harris,Sarett Lewis H,J. R. Egerton,J. J. Yakstis,W. C. Campbell,A. C. Cuckler +9 more
Journal ArticleDOI
Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
TL;DR: The ability of these benzimidazoles to inhibit microtubule polymerization and the mode of action for the anthelmintic benzimdazoles is discussed.