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Book ChapterDOI: 10.1201/9781315370859-20

Modeling and Simulation of Nanobiosystems with Special Reference to Functional Foods and Nutraceuticals

14 Oct 2016-pp 219-236
Abstract: Contents 10.1 Introduction 198 10.2 Molecular simulation: A basic perspective 198 10.3 Application of molecular dynamics simulation in nutraceuticalresearch 200 10.3.1 Vitamins 201 more

Topics: Economic methodology (60%), Applied economics (56%), Human development theory (56%) more

Journal ArticleDOI: 10.1016/J.FCT.2021.112607
Yongqiu Cai1, Yongqiu Cai2, Hooi Ren Lim2, Kuan Shiong Khoo2  +6 moreInstitutions (3)
Abstract: Microalgae metabolites include biologically active compounds with therapeutic effects such as anticancer, anti-inflammatory and immunomodulation effects. One of the most recent focuses is on utilizing microalgae lipid-based biologically active compounds in food applications. However, most microalgae biological active compounds in their natural forms have common drawbacks like low solubility, low physicochemical stability and strong susceptibility to degradation, which significantly limits their application in foods, therefore, it is important to find solutions to retain their functional properties. In the present work, a comprehensive review on multi-product biorefinery was carried out from upstream processing stage to downstream processing stage, and identify critical processes and factors that impact bioactive material acquisition and retention. Furthermore, since nanoencapsulation technology emerges as an effective solution for microalgae nutraceutical product's retention, this work also focus on the nanoparticle perspective and comprehensively reviews the current nanoencapsulation solutions of the microalgae bioactive extract products. The aim is to depict advances in the formulations of microalage bioactive nanoparticles and provide a critical analysis of the reported nanoparticle formation. Overall, through the investigation of microalgae from biomass to bioactive nanoparticles, we aim to facilitate microalgae nutraceuticals incorporation as high value-added ingredients in more functional food that can improve human health. more


Journal ArticleDOI: 10.1126/SCIENCE.1114397
Andre E. Nel1, Tian Xia1, Lutz Mädler1, Ning Li1Institutions (1)
03 Feb 2006-Science
Abstract: Nanomaterials are engineered structures with at least one dimension of 100 nanometers or less. These materials are increasingly being used for commercial purposes such as fillers, opacifiers, catalysts, semiconductors, cosmetics, microelectronics, and drug carriers. Materials in this size range may approach the length scale at which some specific physical or chemical interactions with their environment can occur. As a result, their properties differ substantially from those bulk materials of the same composition, allowing them to perform exceptional feats of conductivity, reactivity, and optical sensitivity. Possible undesirable results of these capabilities are harmful interactions with biological systems and the environment, with the potential to generate toxicity. The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable. more

7,680 Citations

Open accessJournal ArticleDOI: 10.1128/AEM.02218-06
Sukdeb Pal1, Yu Kyung Tak1, Joon Myong Song1Institutions (1)
Abstract: In this work we investigated the antibacterial properties of differently shaped silver nanoparticles against the gram-negative bacterium Escherichia coli, both in liquid systems and on agar plates. Energy-filtering transmission electron microscopy images revealed considerable changes in the cell membranes upon treatment, resulting in cell death. Truncated triangular silver nanoplates with a {111} lattice plane as the basal plane displayed the strongest biocidal action, compared with spherical and rod-shaped nanoparticles and with Ag+ (in the form of AgNO3). It is proposed that nanoscale size and the presence of a {111} plane combine to promote this biocidal property. To our knowledge, this is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and our results demonstrate that silver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli. more

Topics: Silver nanoparticle (66%), Antibacterial agent (55%), Nanoparticle (50%)

3,275 Citations

Journal ArticleDOI: 10.1039/B502142C
Emil Roduner1Institutions (1)
Abstract: Gold is known as a shiny, yellow noble metal that does not tarnish, has a face centred cubic structure, is non-magnetic and melts at 1336 K. However, a small sample of the same gold is quite different, providing it is tiny enough: 10 nm particles absorb green light and thus appear red. The meltingtemperature decreases dramatically as the size goes down. Moreover, gold ceases to be noble, and 2–3 nm nanoparticles are excellent catalysts which also exhibit considerable magnetism. At this size they are still metallic, but smaller ones turn into insulators. Their equilibrium structure changes to icosahedral symmetry, or they are even hollow or planar, depending on size. The present tutorial review intends to explain the origin of this special behaviour of nanomaterials. more

1,575 Citations

Open accessJournal ArticleDOI: 10.1186/1477-3155-5-3
Savita Bisht1, Georg Feldmann1, Sheetal Soni2, Rajani Ravi1  +3 moreInstitutions (2)
Abstract: Curcumin, a yellow polyphenol extracted from the rhizome of turmeric (Curcuma longa), has potent anti-cancer properties as demonstrated in a plethora of human cancer cell line and animal carcinogenesis models. Nevertheless, widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited due to poor aqueous solubility, and consequently, minimal systemic bioavailability. Nanoparticle-based drug delivery approaches have the potential for rendering hydrophobic agents like curcumin dispersible in aqueous media, thus circumventing the pitfalls of poor solubility. We have synthesized polymeric nanoparticle encapsulated formulation of curcumin – nanocurcumin – utilizing the micellar aggregates of cross-linked and random copolymers of N-isopropylacrylamide (NIPAAM), with N-vinyl-2-pyrrolidone (VP) and poly(ethyleneglycol)monoacrylate (PEG-A). Physico-chemical characterization of the polymeric nanoparticles by dynamic laser light scattering and transmission electron microscopy confirms a narrow size distribution in the 50 nm range. Nanocurcumin, unlike free curcumin, is readily dispersed in aqueous media. Nanocurcumin demonstrates comparable in vitro therapeutic efficacy to free curcumin against a panel of human pancreatic cancer cell lines, as assessed by cell viability and clonogenicity assays in soft agar. Further, nanocurcumin's mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFκB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFα). Nanocurcumin provides an opportunity to expand the clinical repertoire of this efficacious agent by enabling ready aqueous dispersion. Future studies utilizing nanocurcumin are warranted in pre-clinical in vivo models of cancer and other diseases that might benefit from the effects of curcumin. more

Topics: Liposomal Curcumin (64%), Curcumin (53%)

971 Citations

Journal ArticleDOI: 10.1021/JF00035A027
Abstract: A method is described for the separation and analysis of isoflavone β-glycoside conjugates and aglucones in various foods derived from soybeans. After initial extraction using 80% aqueous methanol and defatting of the extract with hexane, the isoflavones were analyzed by gradient elution reversed-phase high-pressure liquid chromatography. Their structures were confirmed by fast atom bombardment ionization mass spectrometry and by proton nuclear magnetic resonance spectroscopy. The results reveal that most Asian and American soy products, with the exception of soy sauce, alcohol-extracted soy protein concentrate, and soy protein isolate, have total isoflavone concentrations similar to those in the indict soybean more

Topics: Soy protein (62%), Daidzein (58%), Isoflavones (53%) more

872 Citations

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