Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics
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...…several confounding factors on morphokinetic variables, such as age (Leibenthron et al., 2012; Hampl and Stěpán, 2013), ploidy (Chavez et al., 2012; Campbell et al., 2013a,b), ovarian reserve (Fréour et al., 2012), infertility indication (Wissing et al., 2012), ovarian response to stimulation…...
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...For ICSI/IMSI, where the time-lapse monitoring system and practice allows, the time of the sperm injection may be recorded, per oocyte but otherwise, it is the mid-time point from when injection begins and ends for that patient’s cohort of oocytes....
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...For example ‘irregular divisions’ have been collectively referred to as those from one to three and/or two to five cells in ,5 h (Campbell et al., 2013a,b); the former has also been defined as abrupt division (Meseguer et al., 2011), direct (Rubio et al., 2012), tri-polar cleavage (Wong et al.,…...
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...…of the zona pellucida, at the early cleavage stage, to facilitate herniation of trophectoderm for biopsy, has been reported not to impact downstream development to the full blastocyst stage, compared with unbreached controls (Campbell et al., 2013a). tSB ¼ initiation/start of blastulation....
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...…between embryo kinetics and embryo viability have been demonstrated in various studies (Pribenszky et al., 2010; Wong et al., 2010; Cruz et al., 2011; Meseguer et al., 2011; Azzarello et al., 2012; Campbell et al., 2013b; Chamayou et al., 2013; Herrero et al., 2013; Aguilar et al., 2014)....
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...Although the cause of a temporal delay in aneuploid embryos compared with their euploid counterparts is not yet fully explained, there exist error detection and repair systems within the cell to prevent aneuploidy (Nasmyth and Haering, 2009)....
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"Modelling a risk classification of ..." refers background in this paper
...Recently, it has been shown that the incidence of live birth in young, good-prognosis women, with a theoretically low risk of embryo aneuploidy is enhanced by PGS (Yang et al., 2012)....
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