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Proceedings ArticleDOI

Modelling, design and development of tissue mimicking phantoms for Ultrasound Elastography

TL;DR: This paper deals with both computer modelling and physical design of agar based tissue mimicking phantoms with embedded inclusions of varying stiffness in uniform homogeneous background.
Abstract: Modelling of tissue mimicking phantoms play a crucial role in the development of Ultrasound Elastography This paper deals with both computer modelling and physical design of agar based tissue mimicking phantoms with embedded inclusions of varying stiffness in uniform homogeneous background The elastic properties of agar based phantom are imaged using Ultrasound Elastography The computer modelling and linear strain analysis of the phantom are done using finite element method The visual display of strain results are compared with the experimental results and they are in good agreement This allows us to model many hypothetical structures of real life and will be useful while validating signal processing algorithms for new imaging modalities
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Journal ArticleDOI
TL;DR: In this article, the authors describe and evaluate a setup to create gelatin phantoms by robotic 3D printing and evaluate the reproducibility and resolution of the created phants.
Abstract: Abstract We describe and evaluate a setup to create gelatin phantoms by robotic 3D printing. Key aspects are the large workspace, reproducibility and resolution of the created phantoms. Given its soft tissue nature, the gelatin is kept fluid during inside the system and we present parameters for additive printing of homogeneous, solid objects. The results indicate that 3D printing of gelatin can be an alternative for quickly creating larger soft tissue phantoms without the need for casting a mold.

6 citations

Journal ArticleDOI
TL;DR: In this paper , a binary genetic algorithm (BGA) was used to reconstruct the images of phantoms that mimic the human vascular system produced at a low cost, and the obtained results showed that BGA can be used as an alternative to the reconstruction methods commonly used in digital holography.
Abstract: Since medical imaging is one of the essential methods for the diagnosis and treatment of several diseases, the characterization and calibration of medical imaging systems with low-cost equipment is the most crucial issue. In this context, tissue-mimicking phantoms have long been used for this purpose. The advantage of phantoms is that, in addition to the desired size and internal properties, they can be produced in a way that best carries the characteristic properties of tissue models and can be standardized so that they can be used in imaging environments. For this reason, it is important to make low-cost phantom designs produced from materials that are easy to shape and available and to ensure that they can be imaged with high quality. In this study, digital holography and binary genetic algorithm (BGA) were used to reconstruct the images of phantoms that mimic the human vascular system produced at a low cost. The obtained results showed that BGA can be used as an alternative to the reconstruction methods commonly used in digital holography. Since BGA provides an alternative solution to obtain the image with high resolution in the reconstruction process without any image processing algorithm, it enables the diagnosis of diseases related to thin vascular structures in real-time with a reliable and non-contact method.
References
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Journal ArticleDOI
TL;DR: Initial results of several phantom and excised animal tissue experiments are reported which demonstrate the ability of this technique to quantitatively image strain and elastic modulus distributions with good resolution, sensitivity and with diminished speckle.

3,636 citations


"Modelling, design and development o..." refers background in this paper

  • ...It involves acquiring ultrasound signals from tissues before and after a small static external compression [3]....

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Journal ArticleDOI
TL;DR: In this article, a device and procedure for measuring elastic properties of gelatin for elasticity imaging (elastography) was described. And the measured compression forces were comparable to results obtained from finite element analysis when linear elastic media are assumed.
Abstract: Acoustic and mechanical properties are reported for gelatin materials used to construct tissue-like phantoms for elasticity imaging (elastography). A device and procedure for measuring elastic properties are described. The measured compression forces were comparable to results obtained from finite element analysis when linear elastic media are assumed. Also measured were the stress relaxation, temporal stability, and melting point of the materials. Aldehyde concentration was used to increase the stiffness of the gelatin by controlling the amount of collagen cross-linking. A broad range of tissue-like elastic properties was achieved with these materials, although gels continued to stiffen for several weeks. The precision for elastic modulus measurements ranged from less than 0.1% for 100 kPa samples to 8.9% for soft (<10 kPa), sticky samples.

511 citations

Journal ArticleDOI
TL;DR: Water-based pharmaceutical gels containing uniform distributions of graphite powder and known concentrations of alcohol have been discovered whose attenuation and speed of sound properties not only mimic those of human soft tissue, but are controllable in magnitude.
Abstract: Up until now, no material has been found whose attenuation and speed of sound properties not only mimic those of human soft tissue, but are controllable in magnitude. We have discovered such a material in the form of water-based pharmaceutical gels containing uniform distributions of graphite powder and known concentrations of alcohol. The magnitude of the attenuation coefficient can be controlled easily between 0.2 and 1.5 dB/cm at 1 MHz, by varying the concentration of graphite. These attenuation coefficients are nearly proportional to the frequency. The speed of sound varies between 1520 and 1650 m/s at room temperature, depending primarily upon the concentration of alcohol. Bacterial invasion has been prevented by sterilization procedures and the introduction of appropriate preservatives. The ultrasonic properties exhibit temporal stability and change little over the range of room temperatures.

375 citations


"Modelling, design and development o..." refers background in this paper

  • ...Physical phantoms are developed using hydrogels [4], [5] which are very similar to tissues....

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Proceedings ArticleDOI
16 Jul 2012
TL;DR: This paper deals with the preparation and study of agar based tissue mimicking phantoms and Reproducible phantom preparation procedures for matching various properties of normal and abnormal human soft tissues.
Abstract: Tissue mimicking phantoms play a crucial role in the development of Acoustic Radiation Force Impulse Imaging. This paper deals with the preparation and study of agar based tissue mimicking phantoms. Acoustic and elastic properties are studied for various concentration of agar samples (1.7%–10% by weight). Acoustic properties are measured using pulse echo transmit receive principle. Young's modulus of the samples are measured using compression test. Reproducible phantom preparation procedures are standardised for matching various properties of normal and abnormal human soft tissues.

9 citations


"Modelling, design and development o..." refers methods in this paper

  • ...The preparation procedure and characterisation methods are discussed in our earlier paper [6]....

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