Journal ArticleDOI
Modifying role of Phyllanthus emblica and ascorbic acid against nickel clastogenicity in mice.
Reads0
Chats0
TLDR
Aqueous extract of edible dried fruits of Phyllanthus emblica was fed to Mus musculus for seven consecutive days prior to treatment with different doses of nickel chloride, finding the greater efficacy of the fruit extract could be due to the interaction of its various natural components rather than to any single constituent.About:
This article is published in Cancer Letters.The article was published on 1991-07-26. It has received 59 citations till now. The article focuses on the topics: Dried fruit & Ascorbic acid.read more
Citations
More filters
Journal ArticleDOI
Review on some plants of Indian traditional medicine with antioxidant activity.
Paolo Scartezzini,Ester Speroni +1 more
TL;DR: Seven plants contain antioxidant principles, that can explain and justify their use in traditional medicine in the past as well as the present, and are viewed for their historical, etymological, morphological, phytochemical and pharmacological aspects.
Journal Article
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6^ collaborative study by CSGMT/JEMS MMS. Collaborative study of the Micronucleus Group Test
TL;DR: Structural-activity relationship analysis suggested that the micronucleus assay is more sensitive to the genetic toxicity of some classes of chemicals than to those carcinogens with stronger evidence human carcinogenicity.
Journal ArticleDOI
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group.
Takeshi Morita,Norihide Asano,Takumi Awogi,Yu F. Sasaki,Sei-ichi Sato,Hiroyasu Shimada,Sizuyo Sutou,Takayoshi Suzuki,Akihiro Wakata,Toshio Sofuni,Makoto Hayashi +10 more
TL;DR: In the 6th MMS/CSGMT collaborative study as mentioned in this paper, IARC groups 1 (human carcinogen), 2A (probable human carcinogen) and 2B (possible human carcinogens) were selected from 100 commercially available chemicals and chemical groups on which there was little or no micronucleus assay data.
Journal ArticleDOI
A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.
TL;DR: There is no convincing evidence that any genotoxic rodent carcinogens or in vivo genotoxins would remain undetected in an in vitro test battery consisting of Ames+MNvit.
References
More filters
Journal ArticleDOI
Recent progress in nickel carcinogenesis
TL;DR: Research on nickel carcinogenesis from 1979 to 1983 is reviewed and epidemiological studies have strengthened the evidence that workers in nickel refineries have increased risks of lung and sinonasal cancers, but have not substantiated increased risk of respiratory cancers in other nickel‐exposed workers.
Journal ArticleDOI
Vegetables inhibit, in vivo, the mutagenicity of nitrite combined with nitrosable compounds
TL;DR: The mutagenicity of AP and MU plus NaNO2 may be affected by substances, such as ascorbic acid and tannic acid, that are widely present in plants, and so the system reported above was used to test the possible modulation produced by certain edible vegetables and fruit juices.
Journal ArticleDOI
Antagonistic Activity of Herbal Drug (Phyllanthus emblica) on Cytological Effects of Environmental Chemicals on Mammalian Cells
TL;DR: Phyllanthus emblica Linn, a rich source of vitamin C, has been shown to reduce the clastogenic and mitostatic activities of different known mutagens and antagonises both the spindle disturbance and chromosomal abnormalities caused by ethyl parathion.
Journal ArticleDOI
Inhibition of dietary fat-promoted development of (pre)neoplastic lesions in exocrine pancreas of rats and hamsters by supplemental vitamins A, C and E.
TL;DR: The effects of vitamins A, C and E on the development of putative preneoplastic foci in exocrine pancreas were investigated in azaserine-treated rats and N-nitrosobis(2-oxoproypy)amine-treated hamsters to find out whether vitamin E exerted an inhibitory effect on growth of basophilic but not of acidophilic foci.
Effects of medicinal plant extracts from Chinese herbal medicines on the mutagenic activity of benzo[a]pyrene.
TL;DR: In this article, the effects of medicinal plants on the mutagenicity of benzo[a]pyrene were studied with Salmonella typhimurium tester strains.
Related Papers (5)
Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator.
K Suresh,Damodaran Vasudevan +1 more