Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair
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...Finally, by mimicking the anti-inflammatory effects of apoptotic cells, phosphatidlyserine-presenting liposomes have also been used to induce reparative IL-10and TGFb1-producing cardiac macrophages (Harel-Adar et al., 2011)....
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...Furthermore, recent studies have shown that liposome administration can alter macrophage phenotype in vivo in part by induction of ERK signaling after ingestion (53, 54)....
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590 citations
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...…infarction in rats PS/PC liposomes Induction of angiogenesis, preservation of small scars, prevention of ventricular dilatation and remodelling Harel-Adar et al (2011) Retinal ischaemia in mice PS/PC liposomes Reduced expression of pro-inflammatory genes, reduced neuronal death in the retina…...
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Cites background from "Modulation of cardiac macrophages b..."
...Consistently, experimental modulation of macrophage polarization toward an M2 state has been previously demonstrated to improve wound healing post-MI.(46) Figure 8....
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"Modulation of cardiac macrophages b..." refers background in this paper
...The anti-inflammatory macrophage phenotype after uptake of PS-presenting liposomes mimicked that of activated macrophages after the uptake of apoptotic cells (14, 15)....
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"Modulation of cardiac macrophages b..." refers background in this paper
...Following MI, resident and recruited macrophages remove necrotic and apoptotic cells, secrete cytokines, and modulate angiogenesis at the infarct site (1)....
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"Modulation of cardiac macrophages b..." refers background in this paper
...According to recent studies, different subsets of macrophages are responsible for these different activities; during the early inflammatory phase (phase 1), proinflammatory macrophages dominate the injury site and phagocytose apoptotic/necrotic myocytes and other debris, whereas during inflammation resolution (phase 2), the dominant subsets are the reparative macrophages, which propagate infarct repair (3, 4)....
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1,189 citations